{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T15:44:26Z","timestamp":1794584666557,"version":"4.9.1"},"reference-count":107,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CVP"],"published-print":{"date-parts":[[2020,8,10]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Sj\u00f6gren\u2019s syndrome is a rheumatic autoimmune disease that primarily affects middle-aged\nwomen and runs a slowly progressing course with sicca symptoms being the prevalent manifestation.\nPremature atherosclerosis and increased cardiovascular (CV) morbidity and mortality are frequently\nencountered in rheumatic diseases characterized by significant systemic inflammation, such as the inflammatory\narthritides, systemic vasculitides and systemic lupus erythematosus. In the same context,\nchronic inflammation and immune aberrations underlying Sj\u00f6gren\u2019s syndrome are also reported to be\nassociated with augmented risk of atherosclerosis. Increased CV disease (CVD) frequency has been\nfound in recent meta-analyses. The involvement of the CV system is not a common feature of Sj\u00f6gren\u2019s\nsyndrome; however, specific manifestations, such as autoantibody-mediated heart block, pericarditis,\npulmonary arterial hypertension and dysautonomia, have been described. This review focuses on studies\naddressing CV morbidity in Sj\u00f6gren\u2019s syndrome and presents current data regarding distinct CV features\nof the disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570161118666200129125320","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T13:58:01Z","timestamp":1580306281000},"page":"447-454","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Primary Sj\u00f6gren\u2019s Syndrome and Cardiovascular Disease"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-0623","authenticated-orcid":true,"given":"Konstantinos","family":"Melissaropoulos","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Patras North Sector Health Center, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-7902","authenticated-orcid":true,"given":"Dimitrios","family":"Bogdanos","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41 110, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-1642","authenticated-orcid":true,"given":"Theodoros","family":"Dimitroulas","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine Hippokration Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7670-3314","authenticated-orcid":true,"given":"Lazaros I.","family":"Sakkas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41 110, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-6176","authenticated-orcid":true,"given":"George D.","family":"Kitas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Dudley Group NHS Foundation Trust, Russells Hall Hospital, Dudley, West Midlands, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-3655","authenticated-orcid":true,"given":"Dimitrios","family":"Daoussis","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Patras University Hospital, University of Patras Medical School, Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","volume":"2","author":"Brito-Zer\u00f3n P.","year":"2016","unstructured":"Brito-Zer\u00f3n P.; Baldini C.; Bootsma H.; Sj\u00f6gren syndrome. 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