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Considering\nthe inflammatory process in autoimmune diseases, scientific interest has focused on recently\nintroduced biologic disease-modifying agents (bDMARDS) such as inhibitors of Tumor Necrosis Factor-\n&amp;#945; (\u03a4\u039dF-&amp;#945;), Interleukins -1 (IL-1) and -6 (IL-6). Despite the widespread use of bDMARDS in RA\nand other chronic autoimmune inflammatory diseases, their precise impact on CV disease and outcome\nremains to be elucidated, while prospective randomized control trials assessing their impact on hard CV\nendpoints are scarce. In this review, we summarize current knowledge concerning the effect of\nbDMARDs on CV outcome and on the risk of developing CV disease in patients with systemic autoimmune\nrheumatic diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570161118666200214115532","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T13:26:06Z","timestamp":1581686766000},"page":"488-506","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cardiovascular Effects of Biologic Disease-Modifying Anti-Rheumatic Drugs (DMARDs)"],"prefix":"10.2174","volume":"18","author":[{"given":"Maria","family":"Drakopoulou","sequence":"first","affiliation":[{"name":"First Department of Cardiology, Athens School of Medicine, Hippokration Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-5286","authenticated-orcid":true,"given":"Stergios","family":"Soulaidopoulos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Athens School of Medicine, Hippokration Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-0174","authenticated-orcid":true,"given":"George","family":"Oikonomou","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Athens School of Medicine, Hippokration Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-4984","authenticated-orcid":true,"given":"Dimitrios","family":"Tousoulis","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Athens School of Medicine, Hippokration Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-344X","authenticated-orcid":true,"given":"Konstantinos","family":"Toutouzas","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Athens School of Medicine, Hippokration Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1136\/ard.2010.142133","volume":"70","author":"Kitas G.D.","year":"2011","unstructured":"Kitas G.D.; Gabriel S.E.; Cardiovascular disease in rheumatoid arthritis: state of the art and future perspectives. 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