{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:44:55Z","timestamp":1787165095364,"version":"build-2736575974"},"reference-count":195,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CVP"],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea syndrome\n(OSAS) are among the most prevalent chronic respiratory disorders. Accumulating data suggest that\nthere is a significant burden of cardiovascular disease (CVD) in patients with COPD and OSAS, affecting\nnegatively patients\u2019 quality of life and survival. Overlap syndrome (OS), i.e. the co-existence of\nboth COPD and OSAS in the same patient, has an additional impact on the cardiovascular system multiplying\nthe risk of morbidity and mortality. The underlying mechanisms for the development of CVD in\npatients with either OSAS or COPD and OS are not entirely elucidated. Several mechanisms, in addition\nto smoking and obesity, may be implicated, including systemic inflammation, increased sympathetic\nactivity, oxidative stress and endothelial dysfunction. Early diagnosis and proper management of these\npatients might reduce cardiovascular risk and improve patients' survival. In this review, we summarize\nthe current knowledge regarding epidemiological aspects, pathophysiological mechanisms and present\npoint-to-point specific associations between COPD, OSAS, OS and components of CVD, namely, pulmonary\nhypertension, coronary artery disease, peripheral arterial disease and stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1570161118666200318103553","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T09:00:49Z","timestamp":1584522049000},"page":"285-300","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnoea Syndrome and Overlap Syndrome"],"prefix":"10.2174","volume":"19","author":[{"given":"A.","family":"Voulgaris","sequence":"first","affiliation":[{"name":"MSc Programme in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Archontogeorgis","sequence":"additional","affiliation":[{"name":"MSc Programme in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Steiropoulos","sequence":"additional","affiliation":[{"name":"MSc Programme in Sleep Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-785X","authenticated-orcid":true,"given":"N.","family":"Papanas","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","year":"2019","unstructured":"Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease  2019"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1183\/16000617.0057-2018","volume":"27","author":"Rabe K.F.","year":"2018","unstructured":"Rabe K.F.; Hurst J.R.; Suissa S.; Cardiovascular disease and COPD: dangerous liaisons? 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