{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:21:52Z","timestamp":1747207312015,"version":"3.40.5"},"reference-count":115,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CVP"],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>In Chronic Kidney Disease, vascular calcification (VC) is highly prevalent even at early\nstages and is gradually enhanced, along with disease progression to End-Stage Renal Disease (ESRD).\nThe calcification pattern in uremia includes all types of mineralization and contributes to the heavy\ncardiovascular (CV) burden that is common in these patients. Ectopic mineralization is the result of the\nimbalance between inhibitors and promoters of vascular calcification, with the latter overwhelming the\nformer. The most powerful, natural inhibitor of calcification is Matrix Gla Protein (MGP), a small vitamin\nK dependent protein, secreted by chondrocytes and vascular smooth muscle cells. In uremia, MGP\nwas reported as the only molecule able to reverse VC by \u201csweeping\u201d calcium and hydroxyapatite crystals\naway from the arterial wall. To become biologically active, this protein needs to undergo carboxylation\nand phosphorylation, reactions highly dependent on vitamin K status. The inactive form of MGP\nreflects the deficiency of vitamin K and has been associated with CV events and mortality in ESRD\npatients. During the past decade, vitamin K status has emerged as a novel risk factor for vascular calcification\nand CV disease in various populations, including dialysis patients. This review presents evidence\nregarding the association between vitamin K and CV disease in ESRD patients, which are prone\nto atherosclerosis and atheromatosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570161118666200320111745","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T13:38:48Z","timestamp":1584711528000},"page":"77-90","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin K for the Treatment of Cardiovascular Disease in End-Stage Renal Disease Patients: Is there Hope?"],"prefix":"10.2174","volume":"19","author":[{"given":"Stefanos","family":"Roumeliotis","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Roumeliotis","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Dounousi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, University Hospital of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Eleftheriadis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Medical School, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-2724","authenticated-orcid":true,"given":"Vassilios","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"Jha V.","year":"2013","unstructured":"Jha V.; Garcia-Garcia G.; Iseki K.; Chronic kidney disease: global dimension and perspectives. 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