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Although associations between obesity during pregnancy and adverse maternalfetal\nhealth outcomes are clear, the complex molecular mechanisms underlying maternal obesity remain\nlargely unknown. This review describes multimeric self-assembling protein complexes, namely inflammasomes,\nas potential molecular targets in the pathophysiology of maternal obesity. Inflammasomes are\nimplicated in both normal physiological and in pathophysiological processes that occur in response to an\ninflammatory milieu throughout gestation. This review highlights the current knowledge of inflammasome\nexpression and its activity in pregnancies affected by maternal obesity. Key discussions in defining\npharmacological inhibition of upstream as well as downstream targets of the inflammasome signaling\ncascade; and the inflammasome platform, as a potential therapeutic strategy in attenuating the\npathophysiology underpinning inflammatory component in maternal obesity are presented herein.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570161118666200603131536","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T05:13:36Z","timestamp":1591247616000},"page":"165-175","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inflammasomes in the Pathophysiology of Maternal Obesity: Potential Therapeutic Targets to Reduce Long-Term Adverse Health Outcomes in the Mother and Offspring"],"prefix":"10.2174","volume":"19","author":[{"given":"Padma","family":"Murthi","sequence":"first","affiliation":[{"name":"Cardiovascular Disease Program, Monash Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri","family":"Rajaraman","sequence":"additional","affiliation":[{"name":"First Year College, Victoria University, Melbourne VIC 8001, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1001\/jama.2016.6458","volume":"315","author":"Flegal K.M.","year":"2016","unstructured":"Flegal K.M.; Kruszon-Moran D.; Carroll M.D.; Fryar C.D.; Ogden C.L.; Trends in obesity among adults in the United States, 2005 to 2014. 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