{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T12:25:56Z","timestamp":1648643156378},"reference-count":45,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CVP"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Non-adherence to antihypertensive agents leads to reduced blood pressure\n(BP) control. Data supporting the correlation of adherence with arterial stiffness (AS) are few. Furthermore,\nthe causal relationship between AS and cognitive dysfunction (CO\/DY) has not been\nclearly established. It is suggested that angiotensin II receptor blockers (ARBs) exhibit the lowest\ndiscontinuation rate among antihypertensive drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design and Methods:<\/jats:title>\n<jats:p>We followed up with patients receiving monotherapy with irbesartan.\nCO\/DY was assessed with the Mini-Mental State Examination (M\u039cSE) and other tests.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Patients [n=77; mean age: 56\u00b111 years; 39 men (50.6%)] were followed-up for 16.1\u00b110.9\nmonths. At the end of follow up, significant reductions were observed in mean peripheral systolic\nBP (135\u00b1117 vs 153\u00b111 mmHg; p&lt;0.005), mean peripheral diastolic BP (85\u00b111 vs 95\u00b110 mmHg;\np&lt;0.005), mean central systolic BP (130\u00b111 vs 142\u00b112 mmHg; p&lt;0.005) as well as in mean central\ndiastolic BP (85\u00b18 vs 95\u00b197 mmHg; p&lt;0.005).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>AS indices [carotid-femoral pulse wave velocity and augmentation index] also improved significantly:\n7.7\u00b11.4 vs 8.2\u00b11.4 m\/sec (p&lt;0.005), and 29.1\u00b18.3 vs 32.3\u00b19.1 (p&lt;0.005), respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>At the end of the study, a significant improvement was observed in the MMSE test (29.7\u00b10.7 vs.\n29.2\u00b10.9; p&lt;0.02), as well as a significant reduction in 24h urine albumin (94\u00b182 vs. 204\u00b1112\nmg\/24h, p&lt;0.005).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>The level of adherence was high in 60\/77 (77.9%), medium in 9\/77 (11.6%) and low in 8\/77\n(10.38%) patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Hypertensive patients receiving mono-therapy with an ARB showed reduced AS, cognitive\nimprovement, significant reductions in BP (peripheral and central) and decreased 24h urinary\nalbumin excretion.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570161119666201120160104","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T04:17:32Z","timestamp":1606105052000},"page":"565-571","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adherence to Treatment, Arterial Stiffness and Cognitive Function in Irbesartan- Treated Newly Diagnosed Hypertensive Patients"],"prefix":"10.2174","volume":"19","author":[{"given":"Rigas G.","family":"Kalaitzidis","sequence":"first","affiliation":[{"name":"Hypertension Excellence Centre, Division of Nephrology, University Hospital of Ioannina, Ioannina,Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Balafa","sequence":"additional","affiliation":[{"name":"Hypertension Excellence Centre, Division of Nephrology, University Hospital of Ioannina, Ioannina,Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Dounousi","sequence":"additional","affiliation":[{"name":"Hypertension Excellence Centre, Division of Nephrology, University Hospital of Ioannina, Ioannina,Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Stagikas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Ioannina, Ioannina,Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilios","family":"Tsimihodimos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of Ioannina, Ioannina,Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.15585\/mmwr.mm6632a3","volume":"66","author":"Hales C.M.","year":"2017","unstructured":"Hales C.M.; Carroll M.D.; Simon P.A.; Kuo T.; Ogden C.L.; Hypertension Prevalence, Awareness, Treatment, and Control Among Adults Aged \u226518 Years - Los Angeles County, 1999-2006 and 2007-2014. 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