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The aim of this study is to introduce an herbal antihistamine H2 receptor which is\neffective in these disorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This is a review study by searching the electronic databases and also Persian Medicine books,\nfrom 2000 to 2018 by the keywords such as H2 antagonist, H2 blocker and melasma.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>According to the researched studies, histamine can induce melanogenesis and melasma after a series\nof stages in the body. Also, Histamine, through receptors 2, triggers melasma. Therefore, it can be said\nthat antihistamine H2 receptor can be effective in melasma. Considering chemical antihistamine, H2 receptors\nhave side effects, such as digestive problems, H2 antagonists can be used in the treatment of diseases\nsuch as dyspepsia but they have multiple complications. On the other hand, there is an herbal H2 antagonist\nthat can be useful for melasma due to having some special properties.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Herbal H2 blockers should be noted in melasma treatment along with the topical drugs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570163816666190121145653","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T11:54:00Z","timestamp":1548158040000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Herbal H2 Blocker in Melasma Treatment"],"prefix":"10.2174","volume":"17","author":[{"given":"Marjan","family":"Mahjour","sequence":"first","affiliation":[{"name":"Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Khoushabi","sequence":"additional","affiliation":[{"name":"Health Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"e65578","DOI":"10.5812\/jssc.65578","volume":"3(2)","author":"Mahjour,M.","year":"2016","unstructured":"Mahjour,M.; Khoushabi,A.; Noras,MR.; Salari,R. 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