{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:22:07Z","timestamp":1788560527315,"version":"build-2803163510"},"reference-count":31,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["4982"],"award-info":[{"award-number":["4982"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDDT"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>The aim of this study was to evaluate the efficacy of honey-based ophthalmic drop\nin patients with foreign body induced corneal ulcer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Honey is traditionally used for skin, mucosal and corneal ulcers. Its use is well stu<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In this randomized clinical trial, 50 patients with foreign body induced corneal ulcer\nwere allocated to receive 70% sterile honey-based ophthalmic formulation or 0.3% ophthalmic\nciprofloxacin, as the standard treatment every 6 hours. All the patients were examined for the size\nof corneal epithelial defect, corneal infiltration and depth and followed on a daily basis until complete\nhealing. Duration for complete healing was considered as the outcome measure. Smear, culture,\nantibiogram and minimum inhibition concentration (MIC) tests were performed for honey\nand ciprofloxacin in all patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The average durations of complete healing of corneal epithelial defect in the honey and\nciprofloxacin groups were 3.88 \u00b1 3.44 vs. 6.32 \u00b1 3.69days, respectively (p=0.020). No significant\ndifference was observed between two groups regarding an average duration of healing of corneal\ninfiltration (8.12 \u00b11.94 days vs. 8.64\u00b12.15 days, p=0.375). MIC of honey for pseudomonas aeruginosa\nwas 60%w\/w, for E.Coli 40% w\/w, and for staphylococcus aureus 30% w\/w.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Honey based ophthalmic drop can acceleratethe corneal epithelial defect healing in\npatients with foreign body induced corneal ulcer, compared to ophthalmic ciprofloxacin as a\nstandard treatment.\nThe study was registered in Iranian registry of clinical trial center (IRCT) with registration number\nIRCT2015020120892N1.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570163817666200214113055","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T13:26:06Z","timestamp":1581686766000},"page":"457-462","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Honey-based Ophthalmic Formulation in Patients with Corneal Ulcer: A Randomized Clinical Trial"],"prefix":"10.2174","volume":"18","author":[{"given":"Mahmood","family":"Nejabat","sequence":"first","affiliation":[{"name":"Poostchi Eye Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Soltanzadeh","sequence":"additional","affiliation":[{"name":"Poostchi Eye Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Yasemi","sequence":"additional","affiliation":[{"name":"Poostchi Eye Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Daneshamouz","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin Reza","family":"Akbarizadeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-0936","authenticated-orcid":true,"given":"Mojtaba","family":"Heydari","sequence":"additional","affiliation":[{"name":"Poostchi Eye Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3109\/02713683.2010.544441","volume":"36","author":"Uwaydat S.","year":"2011","unstructured":"Uwaydat S.; Jha P.; Tytarenko R.; The use of topical honey in the treatment of corneal abrasions and endotoxin-induced keratitis in an animal model. 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