{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:17:48Z","timestamp":1793125068919,"version":"4.5.0"},"reference-count":80,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDDT"],"published-print":{"date-parts":[[2021,2,19]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Sciatica is a common back pain caused by irritation of the sciatic nerve. Current\npharmacologic therapies have proven inadequate for many patients with sciatic pain. On the\nother hand, there is a globally increasing demand for the use and administration of natural\nmedicaments for this disorder. Traditional Persian Medicine (TPM) is a school of medicine and\na medicinal plant-based resource for clinical studies put forward by Persian scholars. The aim of\nthe present study is to gather and study the effectiveness of all medicinal plants from five main\nPersian pharmacopeias. Furthermore, different databases such as PubMed and Scopus have been\nchecked to derive relevant activities for these plants. In all, 99 medicinal plants related to 42\nfamilies have been authenticated. Asteraceae and Apiaceae were the most frequent families and\nroots and seeds were the most reported botanical parts. The employed routes of administration\nwere oral (54%), topical (33%) and rectal (13%). Anti-inflammatory, analgesic activity and antinociceptive\nproperties of medicines are known as some main mechanisms to manage sciatic\npain. These functions are possessed by 30%, 15%, and 15% of the studied plants, respectively.\nMedicaments that can be introduced as lead agents for further investigation are Zingiber officinale\nRoscoe, Olea europaea L., Strychnos nux-vomica L and Artemisia vulgaris L which\nshowed all of these properties in previous studies. Hence, conducting adducible clinical trials\nusing these lead agents may lead to novel drugs with lesser undesirable and much more therapeutic\neffects on controlling sciatic pain.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570163817666200316112120","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T13:48:00Z","timestamp":1584366480000},"page":"194-206","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Traditional Aspects of Sciatic Pain Management and Allied Therapies from Persian Medical Reports"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-7057","authenticated-orcid":true,"given":"Ramin","family":"Ansari","sequence":"first","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-2507","authenticated-orcid":true,"given":"Amirhossein","family":"Dadbakhsh","sequence":"additional","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-2998","authenticated-orcid":true,"given":"Fatemeh","family":"Hasani","sequence":"additional","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0100-3855","authenticated-orcid":true,"given":"Fatemeh","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Abolhassanzadeh","sequence":"additional","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-4993","authenticated-orcid":true,"given":"Mohammad M.","family":"Zarshenas","sequence":"additional","affiliation":[{"name":"Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz,Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"704","author":"Jahan N.","year":"2009","unstructured":"Jahan N.;  Eksir-e-Azam 2009,704-753","journal-title":"Eksir-e-Azam"},{"key":"ref=2","year":"1990","unstructured":"Translated to Persian by: Tabatabai SM Tehran: Nashre Sherkate Darusazie Alhavi.  Alhavi fi teb MZ R.1990"},{"key":"ref=3","author":"Sina AI","unstructured":"Sina AI;  Al-Qanun fi al-tibb2005","journal-title":"Al-Qanun fi al-tibb2005"},{"key":"ref=4","first-page":"381","volume":"1370","author":"Attar H.","year":"1888","unstructured":"Attar H.; Ikhtiyarat-e-badiyee. Lucknow, India Munshi Nawal Kishore 1888,1370,381","journal-title":"Lucknow, India Munshi Nawal Kishore"},{"key":"ref=5","author":"Tunakabuni M.","year":"2007","unstructured":"Tunakabuni M.;  Tuhfat al-Mu\u2019minin 2007","journal-title":"Tuhfat al-Mu\u2019minin"},{"key":"ref=6","author":"Shirazi A.","year":"2009","unstructured":"Shirazi A.;  Makhzan Al-adviyah (the Storehouse of medicaments) 2009","journal-title":"Makhzan Al-adviyah (the Storehouse of medicaments)"},{"key":"ref=7","author":"Ghahreman A.","year":"2010","unstructured":"Ghahreman A.; Okhovvat A.R.;  Matching the old medicinal plant names with scientific terminology 2010","journal-title":"Matching the old medicinal plant names with scientific terminology"},{"key":"ref=8","author":"Khare C.P.","year":"2008","unstructured":"Khare C.P.;  Indian medicinal plants: an illustrated dictionary 2008","journal-title":"Indian medicinal plants: an illustrated dictionary"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jep.2008.12.011","volume":"122","author":"Kim H.","year":"2009","unstructured":"Kim H.; Han T-H.; Lee S-G.; Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells. J Ethnopharmacol 2009,122(1),149-156","journal-title":"J Ethnopharmacol"},{"key":"ref=10","first-page":"1","volume":"7","author":"Khurana N.","year":"2015","unstructured":"Khurana N.; Jain P.K.; Pounikar Y.; Sharma N.; Pharmacological evaluation of rhizomes of acorus calamus for analgesic activity. Int J Pharm Pharm Sci 2015,7(1),1","journal-title":"Int J Pharm Pharm Sci"},{"key":"ref=11","volume":"31","author":"Jayanthi M.","year":"2011","unstructured":"Jayanthi M.; Dhar M.; Jayanthi M.; Anti-inflammatory effects of Allium sativum (Garlic) in experimental Rats. Biomedicine (Taipei) 2011,31(1)","journal-title":"Biomedicine (Taipei)"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1211\/jpp.59.6.0016","volume":"59","author":"Mencherini T.","year":"2007","unstructured":"Mencherini T.; Cau A.; Bianco G.; Della Loggia R.; Aquino R.P.; Autore G.; An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties. J Pharm Pharmacol 2007,59(6),891-897","journal-title":"J Pharm Pharmacol"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1080\/13880200902939283","volume":"47","author":"Ramezani M.","year":"2009","unstructured":"Ramezani M.; Nasri S.; Yassa N.; Antinociceptive and anti-inflammatory effects of isolated fractions from Apium graveolens seeds in mice. Pharm Biol 2009,47(8),740-743","journal-title":"Pharm Biol"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00580-015-2082-3","volume":"24","author":"Panahi Y.","year":"2015","unstructured":"Panahi Y.; Dadjo Y.; Pishgoo B.; Akbari A.; Sahebkar A.; Clinical evaluation of the anti-inflammatory effects of Heracleum persicum fruits. Comp Clin Pathol 2015,24(4),971-974","journal-title":"Comp Clin Pathol"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jep.2009.05.012","volume":"124","author":"Hajhashemi V.","year":"2009","unstructured":"Hajhashemi V.; Sajjadi S.E.; Heshmati M.; Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. J Ethnopharmacol 2009,124(3),475-480","journal-title":"J Ethnopharmacol"},{"key":"ref=16","first-page":"239","volume":"8","author":"Benson K.F.","year":"2015","unstructured":"Benson K.F.; Newman R.A.; Jensen G.S.; Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (nae-8.(&#xAE;)) Clin Cosmet Investig Dermatol 2015,8,239-248","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jep.2012.12.048","volume":"146","author":"de Almeida A.B.A.","year":"2013","unstructured":"de Almeida A.B.A.; S&#xE1;nchez-Hidalgo M.; Mart&#xED;n A.R.; Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model. J Ethnopharmacol 2013,146(1),300-310","journal-title":"J Ethnopharmacol"},{"key":"ref=18","first-page":"463","volume":"7","author":"Afsar S","year":"2013","unstructured":"Afsar S; Kumar KR; Gopal JV; Raveesha P; Assessment of antiinflammatory activity of Artemisia vulgaris leaves by cotton pellet granuloma method in Wistar albino rats. journal of pharmacy research 2013,7(6),463-467"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/ptr.2589","volume":"23","author":"Pires J.M.","year":"2009","unstructured":"Pires J.M.; Mendes F.R.; Negri G.; Duarte-Almeida J.M.; Carlini E.A.; Antinociceptive peripheral effect of Achillea millefolium L. and Artemisia vulgaris L.: both plants known popularly by brand names of analgesic drugs. Phytother Res 2009,23(2),212-219","journal-title":"Phytother Res"},{"key":"ref=20","first-page":"463","volume":"7","author":"Parente L.M.L.","year":"2012","unstructured":"Parente L.M.L.; J&#xFA;nior L.; de Souza R.; Assessment of anti-inflammatory activity of Artemisia vulgaris leaves by cotton pellet granuloma method in Wistar albino rats. J Pharm Res 2012,7(6),463-467","journal-title":"J Pharm Res"},{"key":"ref=21","first-page":"45","volume":"3","author":"Shahidi S.","year":"2012","unstructured":"Shahidi S.; Mahmoodi M.; Farahmandlou N.; Antinociceptive properties of hydro-alcoholic extract of calendula officinalis in rat. Basic Clin Neurosci 2012,3(5),45-48","journal-title":"Basic Clin Neurosci"},{"key":"ref=22","first-page":"57","volume":"18","author":"Fallahzadeh A.","year":"2016","unstructured":"Fallahzadeh A.; Mohammadi S.; An Investigation of the antinociceptive and anti-inflammatory effects of hydroalcoholic extract of inula helenium on male rats. Majallah-i Danishgah-i Ulum-i Pizishki-i Babul 2016,18(12),57-63","journal-title":"Majallah-i Danishgah-i Ulum-i Pizishki-i Babul"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.7324\/JAPS.2016.600122","volume":"6","author":"Chandrasenan P.","year":"2016","unstructured":"Chandrasenan P.; Anjumol V.; Neethu M.; Selvaraj R.; Anandan V.; Jacob G.M.; Cytoprotective and antiinflammatory effect of polyphenolic fraction from Red cabbage (Brassica oleracea Linn var. capitata f rubra) in experimentally induced ulcerative colitis. J Appl Pharm Sci 2016,6(1),137-146","journal-title":"J Appl Pharm Sci"},{"key":"ref=24","first-page":"225","volume":"4","author":"Hasan M.","year":"2015","unstructured":"Hasan M.; Al-Mahamud R.; Rahman S.; Ahmad I.; Rahmatullah M.; A preliminary report on antihyperglycemic and analgesic properties of methanol extract of Brassica oleracea L. var. italica sprouts. World J Pharm Pharm Sci 2015,4(09),225-234","journal-title":"World J Pharm Pharm Sci"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.jep.2011.12.013","volume":"139","author":"Su S.","year":"2012","unstructured":"Su S.; Hua Y.; Wang Y.; Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. J Ethnopharmacol 2012,139(2),649-656","journal-title":"J Ethnopharmacol"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12906-017-1569-7","volume":"17","author":"El Azhary K.","year":"2017","unstructured":"El Azhary K.; Tahiri Jouti N.; El Khachibi M.; Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression. BMC Complement Altern Med 2017,17(1),81","journal-title":"BMC Complement Altern Med"},{"key":"ref=27","first-page":"1326","volume":"1","author":"Parimala S.","year":"2009","unstructured":"Parimala S.; Shashidhar G.; Sridevi C.; Jyothi V.; Suthakaran R.; Anti-inflammatory activity of Celastrus paniculatus seeds. Int J Pharm Tech Res 2009,1,1326-1329","journal-title":"Int J Pharm Tech Res"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0378-8741(94)90085-X","volume":"42","author":"Ahmad F.","year":"1994","unstructured":"Ahmad F.; Khan R.A.; Rasheed S.; Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. J Ethnopharmacol 1994,42(3),193-198","journal-title":"J Ethnopharmacol"},{"key":"ref=29","first-page":"665","volume":"15","author":"Marzouk B.","year":"2011","unstructured":"Marzouk B.; Marzouk Z.; Fenina N.; Bouraoui A.; Aouni M.; Anti-inflammatory and analgesic activities of Tunisian Citrullus colocynthis Schrad. immature fruit and seed organic extracts. Eur Rev Med Pharmacol Sci 2011,15(6),665-672","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref=30","first-page":"22","volume":"3","author":"Marzouk B.","year":"2013","unstructured":"Marzouk B.; Haloui E.; Fenina N.; Aouni M.; Marzouk Z.; Comparative evaluation of the analgesic activity of several populations of Tunisian Citrullus colocynthis Schrad. immature fruits. J Appl Pharm Sci 2013,3(5),22","journal-title":"J Appl Pharm Sci"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jep.2004.04.023","volume":"94","author":"Vouldoukis I.","year":"2004","unstructured":"Vouldoukis I.; Lacan D.; Kamate C.; Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity. J Ethnopharmacol 2004,94(1),67-75","journal-title":"J Ethnopharmacol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/ptr.2650030210","volume":"3","author":"Yesilada E.","year":"1989","unstructured":"Yesilada E.; Tanaka S.; Tabata M.; Sezik E.; Antiinflammatory effects of the fruit juice of Ecballium elaterium on edemas in mice. Phytother Res 1989,3(2),75-76","journal-title":"Phytother Res"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/ptr.2650090211","volume":"9","author":"Agil M.A.","year":"1995","unstructured":"Agil M.A.; Risco S.; Miro M.; Navarro M.; Ocete M.; Jim&#xE9;nez J.; Analgesic and antipyretic effects of Ecballium elaterium (L.) A. Richard. Extract in rodents. Phytother Res 1995,9(2),135-138","journal-title":"Phytother Res"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/ptr.2809","volume":"23","author":"Zduni\u0107 G.","year":"2009","unstructured":"Zduni\u0107 G.; Go\u0111evac D.; Milenkovi\u0107 M.; Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytother Res 2009,23(11),1559-1564","journal-title":"Phytother Res"},{"key":"ref=35","first-page":"68","author":"Zhu S.J.","year":"2004","unstructured":"Zhu S.J.; Hu R.; Jia Y.R.; Guo W.Y.; Zhu B.S.K.S.J.; Ku B.S.; Antinociceptive effect of extraction of Hypericum perforatum Linn and vitamin Bs on the pain caused by formaldehyde in mice. Zhongguo Linchuang Kangfu 2004(8),68","journal-title":"Zhongguo Linchuang Kangfu"},{"key":"ref=36","author":"Kumar V","year":"2001","unstructured":"Kumar V; Singh P; Bhattacharya S;  Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L 2001","journal-title":"Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0378-8741(00)00238-5","volume":"73","author":"Hosseinzadeh H.","year":"2000","unstructured":"Hosseinzadeh H.; Ramezani M.; Salmani G.; Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol 2000,73(3),379-385","journal-title":"J Ethnopharmacol"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jep.2003.12.016","volume":"91","author":"Ramezani M.","year":"2004","unstructured":"Ramezani M.; Hosseinzadeh H.; Samizadeh S.; Antinociceptive effects of Zataria multiflora Boiss fractions in mice. J Ethnopharmacol 2004,91(1),167-170","journal-title":"J Ethnopharmacol"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000333555","volume":"21","author":"Hajhashemi V.","year":"2012","unstructured":"Hajhashemi V.; Zolfaghari B.; Yousefi A.; Antinociceptive and anti-inflammatory activities of Satureja hortensis seed essential oil, hydroalcoholic and polyphenolic extracts in animal models. Med Princ Pract 2012,21(2),178-182","journal-title":"Med Princ Pract"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jep.2011.10.038","volume":"139","author":"Chen J.","year":"2012","unstructured":"Chen J.; Wang X.; Qu Y.G.; Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition. J Ethnopharmacol 2012,139(1),181-188","journal-title":"J Ethnopharmacol"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1248\/bpb.19.127","volume":"19","author":"Cai B.","year":"1996","unstructured":"Cai B.; Nagasawa T.; Kadota S.; Hattori M.; Namba T.; Kuraishi Y.; Processing of nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos nux-vomica in mice. Biol Pharm Bull 1996,19(1),127-131","journal-title":"Biol Pharm Bull"},{"key":"ref=42","first-page":"131","volume":"20","author":"&#xD6;zdemir H.","year":"2015","unstructured":"&#xD6;zdemir H.; Yaren B.; Oto G.; Antinociceptive activity of aqueous extract of Lepidium sativum L. in mice. East J Med 2015,20(3),131-135","journal-title":"East J Med"},{"key":"ref=43","first-page":"170","volume":"23","author":"Hamiad M.","year":"2013","unstructured":"Hamiad M.; Numan I.T.; Hassan A.F.; Evaluation of anti-inflammatory effect of ethyl acetate and methanol extracts of loranthus europaeus in experimental models of acute inflammation in rats. Int J Pharm Sci Rev Res 2013,23,170-174","journal-title":"Int J Pharm Sci Rev Res"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"PH10","DOI":"10.1055\/s-0029-1234727","volume":"75","author":"Sleiman N.","year":"2009","unstructured":"Sleiman N.; Daher C.; Malva sylvestris water extract: a potential anti-inflammatory and anti-ulcerogenic remedy. Planta Med 2009,75(09),PH10","journal-title":"Planta Med"},{"key":"ref=45","first-page":"454","volume":"28","author":"Esteves P.F.","year":"2009","unstructured":"Esteves P.F.; Sato A.; Esquibel M.A.; de Campos-Buzzi F.; Meira A.V.; Cechinel-Filho V.; Antinociceptive activity of Malva sylvestris L. Lat Am J Pharm 2009,28(3),454-456","journal-title":"Lat Am J Pharm"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3329\/bjp.v11i3.27000","volume":"11","author":"Akacha M.","year":"2016","unstructured":"Akacha M.; Lahbib K.; Daami-Remadi M.; Boughanmi N.G.; Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract. Bangladesh J Pharmacol 2016,11(3),666-674","journal-title":"Bangladesh J Pharmacol"},{"key":"ref=47","volume":"2","author":"Samdani V.","year":"2010","unstructured":"Samdani V.; Rana A.; Evaluation of hydroalcoholic extract of Melia azedarach Linn roots for analgesic and anti-inflammatory activity. Int J Phytomed 2010,2(3)","journal-title":"Int J Phytomed"},{"key":"ref=48","first-page":"30","volume":"4","author":"Satya V.","year":"2016","unstructured":"Satya V.; Paridhavi M.; Evaluation of anti-inflammatory activity of Anamirta cocculus Linn. fruit. Int J Res Pharm Sci 2016,4(1),30-35","journal-title":"Int J Res Pharm Sci"},{"key":"ref=49","doi-asserted-by":"crossref","first-page":"052","DOI":"10.7324\/JAPS.2015.50510","volume":"5","author":"Kumar MP","year":"2015","unstructured":"Kumar MP; Joshi SD; Kulkarni V; Savant C; Phytochemical screening and evaluation of analgesic, anti-inflammatory activities of Peganum harmala Linn., seeds in rodents. J App Pharm Sci 2015,5(5),052-55","journal-title":"J App Pharm Sci"},{"key":"ref=50","first-page":"65","volume":"7","author":"Monsef H.R.","year":"2004","unstructured":"Monsef H.R.; Ghobadi A.; Iranshahi M.; Abdollahi M.; Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. J Pharm Pharm Sci 2004,7(1),65-69","journal-title":"J Pharm Pharm Sci"},{"key":"ref=51","first-page":"119","volume":"13","author":"Sahranavard S.","year":"2014","unstructured":"Sahranavard S.; Kamalinejad M.; Faizi M.; Evaluation of anti-inflammatory and anti-nociceptive effects of defatted fruit extract of Olea europaea. Iran J Pharm Res 2014,13(Suppl.),119-123","journal-title":"Iran J Pharm Res"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1021\/np300783a","volume":"76","author":"Nieto F.R.","year":"2013","unstructured":"Nieto F.R.; Cobos E.J.; Entrena J.M.; Parra A.; Garc&#xED;a-Granados A.; Baeyens J.M.; Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. J Nat Prod 2013,76(4),737-740","journal-title":"J Nat Prod"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"453","DOI":"10.18203\/2319-2003.ijbcp20150015","volume":"4","author":"Ezeja M.","year":"2015","unstructured":"Ezeja M.; Samuel O.S.; Omeh Y.; Chibiko C.; Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice. Int J Basic Clin Pharmacol 2015,4,453-457","journal-title":"Int J Basic Clin Pharmacol"},{"key":"ref=54","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/(SICI)1099-1573(199808)12:5<346::AID-PTR307>3.0.CO;2-A","volume":"12","author":"G&#xF3;mez\u2010Serranillos M.","year":"1998","unstructured":"G&#xF3;mez\u2010Serranillos M.; Palomino O.; Carretero E.; Villar A.; Analytical study and analgesic activity of oripavine from Papaver somniferum L. Phytother Res 1998,12(5),346-349","journal-title":"Phytother Res"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.biopha.2017.02.066","volume":"89","author":"Makchuchit S.","year":"2017","unstructured":"Makchuchit S.; Rattarom R.; Itharat A.; The anti-allergic and anti-inflammatory effects of Benjakul extract (a Thai traditional medicine), its constituent plants and its some pure constituents using in vitro experiments. Biomed Pharmacother 2017,89,1018-1026","journal-title":"Biomed Pharmacother"},{"key":"ref=56","first-page":"47","volume":"27","author":"Jahan I.","year":"2014","unstructured":"Jahan I.; Akbar P.; Khan N.; Comparative study of anti-nociceptive activity and phenolic content of the ethanol extracts of Piper nigrum and Piper longum fruits. Int J Pharm Sci Rev Res 2014,27(27),47-52","journal-title":"Int J Pharm Sci Rev Res"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4103\/0975-9476.172382","volume":"6","author":"Tripathi R.K.","year":"2015","unstructured":"Tripathi R.K.; Bolegave S.S.; Shetty P.A.; Efficacy and safety of a polyherbal formulation in hemorrhoids. J Ayurveda Integr Med 2015,6(4),225-232","journal-title":"J Ayurveda Integr Med"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1076\/phbi.35.2.99.13288","volume":"35","author":"N&#xFA;&#xF1;ez Guill&#xE9;n M.E.","year":"1997","unstructured":"N&#xFA;&#xF1;ez Guill&#xE9;n M.E.; da Silva Emim J.A.; Souccar C.; Lapa A.J.; Analgesic and anti-inflammatory activities of the aqueous extract of Plantago major L. Int J Pharmacol 1997,35(2),99-104","journal-title":"Int J Pharmacol"},{"key":"ref=59","first-page":"137","volume":"72","author":"Tomovic M.T.","year":"2015","unstructured":"Tomovic M.T.; Cupara S.M.; Popovic-Milenkovic M.T.; Ljujic B.T.; Kostic M.J.; Jankovic S.M.; Antioxidant and anti-inflammatory activity of Potentilla reptans L. Acta Pol Pharm 2015,72(1),137-145","journal-title":"Acta Pol Pharm"},{"key":"ref=60","first-page":"272","volume":"7","author":"Giresha A.S.","year":"2015","unstructured":"Giresha A.S.; Anitha M.G.; Dharmappa K.K.; Phytochemical composition, antioxidant and in-vitro anti-inflammatory activity of ethanol extract of Ruta Graveolens L. leaves. Int J Pharm Pharm Sci 2015,7(10),272-276","journal-title":"Int J Pharm Pharm Sci"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4314\/ajtcam.v11i3.25","volume":"11","author":"Loonat F.","year":"2014","unstructured":"Loonat F.; Amabeoku G.J.; Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats. Afr J Tradit Complement Altern Med 2014,11(3),173-181","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jep.2008.10.009","volume":"121","author":"Khan I.","year":"2009","unstructured":"Khan I.; Nisar M.; Ebad F.; Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies. J Ethnopharmacol 2009,121(1),175-177","journal-title":"J Ethnopharmacol"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jep.2005.08.004","volume":"103","author":"Shu X-S.","year":"2006","unstructured":"Shu X-S.; Gao Z-H.; Yang X-L.; Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract. J Ethnopharmacol 2006,103(3),327-332","journal-title":"J Ethnopharmacol"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.fitote.2009.08.024","volume":"81","author":"Begum S.","year":"2010","unstructured":"Begum S.; Saxena B.; Goyal M.; Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan. Fitoterapia 2010,81(3),178-184","journal-title":"Fitoterapia"},{"key":"ref=65","first-page":"777","volume":"29","author":"Gilani A.H.","year":"2010","unstructured":"Gilani A.H.; In vivo studies on the bronchodilatory and analgesic activities of Hyoscyamus niger and Aspalathus linearis. Lat Am J Pharm 2010,29(5),777","journal-title":"Lat Am J Pharm"},{"key":"ref=66","first-page":"1","volume":"10","author":"Hassan N.","year":"2017","unstructured":"Hassan N.; Karunakaran R.; Uma S.; Anti-inflammatory effect of Zingiber officinale on Sprague Dawley rats. Asian J Pharm Clin Res 2017,10(3),1-3","journal-title":"Asian J Pharm Clin Res"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4103\/0253-7613.19856","volume":"38","author":"Vendruscolo A.","year":"2006","unstructured":"Vendruscolo A.; Takaki I.; Bersani-Amado L.; Dantas J.; Bersani-Amado C.; Cuman R.K.; Antiinflammatory and antinociceptive activities of zingiber officinale roscoe essential oil in experimental animal models. Indian J Pharmacol 2006,38(1),58","journal-title":"Indian J Pharmacol"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/ptr.1952","volume":"20","author":"Ojewole J.A.","year":"2006","unstructured":"Ojewole J.A.; Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res 2006,20(9),764-772","journal-title":"Phytother Res"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00011-009-0037-3","volume":"58","author":"Garc&#xED;a-Lafuente A.","year":"2009","unstructured":"Garc&#xED;a-Lafuente A.; Guillam&#xF3;n E.; Villares A.; Rostagno M.A.; Mart&#xED;nez J.A.; Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res 2009,58(9),537-552","journal-title":"Inflamm Res"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/0306-9877(92)90059-L","volume":"39","author":"Srivastava K.C.","year":"1992","unstructured":"Srivastava K.C.; Mustafa T.; Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses 1992,39(4),342-348","journal-title":"Med Hypotheses"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"425","DOI":"10.2174\/138620706777698481","volume":"9","author":"Geronikaki A.A.","year":"2006","unstructured":"Geronikaki A.A.; Gavalas A.M.; Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity. Comb Chem High Throughput Screen 2006,9(6),425-442","journal-title":"Comb Chem High Throughput Screen"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2165\/00003495-199600525-00004","volume":"52","author":"Cashman J.N.","year":"1996","unstructured":"Cashman J.N.; The mechanisms of action of NSAIDs in analgesia. Drugs 1996,52(5)(Suppl. 5),13-23","journal-title":"Drugs"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1399-6576.1997.tb04623.x","volume":"41","author":"Yaksh T.L.","year":"1997","unstructured":"Yaksh T.L.; Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 1997,41(1 Pt 2),94-111","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/ana.410130418","volume":"13","author":"Spiegel K.","year":"1983","unstructured":"Spiegel K.; Kalb R.; Pasternak G.W.; Analgesic activity of tricyclic antidepressants. Ann Neurol 1983,13(4),462-465","journal-title":"Ann Neurol"},{"key":"ref=75","doi-asserted-by":"crossref","first-page":"160","DOI":"10.53388\/TMR20190414115","volume":"4","author":"Ebrahimi F.","year":"2019","unstructured":"Ebrahimi F.; Torbati M.; Khoshbakht Z.; Khodaie L.; Application of herbal rectal suppositories beyond intestinal disorders in Persian medicine. Traditional Med Res 2019,4(3),160-172","journal-title":"Traditional Med Res"},{"key":"ref=76","author":"El Gabbas Z.","year":"2019","unstructured":"El Gabbas Z.; Bezza K.; Laadraoui J.;  Salvia officinalis, rosmarinic and caffeic acids attenuate neuropathic pain and improve function recovery after sciatic nerve chronic constriction in mice 2019","journal-title":"Salvia officinalis, rosmarinic and caffeic acids attenuate neuropathic pain and improve function recovery after sciatic nerve chronic constriction in mice"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/jpri\/2019\/v27i430174","author":"Malek V.G.","year":"2019","unstructured":"Malek V.G.; Parvari S.; Abbassian A.;  Low back pain treatments in traditional Iranian medicine 2019,1-9","journal-title":"Low back pain treatments in traditional Iranian medicine"},{"key":"ref=78","author":"Chebbi Mahjoub R.","year":"2011","unstructured":"Chebbi Mahjoub R.; Khemiss M.; Dhidah M.; Della&#xEF; A.; Bouraoui A.; Khemiss F.; Chloroformic and methanolic extracts of Olea europaea L. leaves present anti-inflammatory and analgesic activities. ISRN Pharmacol 2011","journal-title":"ISRN Pharmacol"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s10616-014-9723-2","volume":"67","author":"Eldahshan O.A.","year":"2015","unstructured":"Eldahshan O.A.; Abdel-Daim M.M.; Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica. Cytotechnology 2015,67(5),831-844","journal-title":"Cytotechnology"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/22311866.2013.782761","volume":"3","author":"Ashok PK","year":"2013","unstructured":"Ashok PK; Upadhyaya K; Evaluation of analgesic and antiinflammatory activities of aerial parts of Artemisia vulgaris L. in experimental animal models. J Biological Active Prod Nat 2013,3(1),101-105","journal-title":"J Biological Active Prod Nat"}],"container-title":["Current Drug Discovery Technologies"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/180228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.eurekaselect.com\/180228\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eurekaselect.com\/article\/download\/180228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T14:44:43Z","timestamp":1641134683000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/180228\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,19]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1570163817666200316112120","relation":{},"ISSN":["1570-1638"],"issn-type":[{"value":"1570-1638","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,19]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}