{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:04:37Z","timestamp":1768259077746,"version":"3.49.0"},"reference-count":29,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDDT"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Garlic (Allium sativum) is used as a natural supplement for the treatment of\nvarious diseases and disorders because it has antibacterial, antiviral, antifungal, antiparasitic,\nantioxidant, and anti-inflammatory properties. This systematic review aimed to evaluate in vitro and in\nvivo effects of garlic against Schistosoma spp.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method:<\/jats:title>\n<jats:p>The current study was carried out according to the PRISMA guidelines and registered in the\nCAMARADES-NC3Rs Preclinical Systematic Review and Meta-analysis Facility [SyRF] database.\nThe literature search was conducted using five databases, including Scopus, PubMed, Web of Science,\nEmbase, and Google Scholar, from January 2008 to January 2021. The search was restricted to articles\npublished in the English language. Syntax was performed based on each database tag.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Out of 2,600 studies, 10 met the eligibility criteria for review. The examined parasite in all\nstudies was Schistosoma mansoni. Ten studies (90%) were performed in vivo and one study in vitro.\nStudies have shown that garlic compounds can activate immune system factors, thereby damaging the\nparasite structure or its eggs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Given the increase in using plants in the treatment of many diseases and the fact that\nplants can be a good alternative to chemical drugs in many cases, more comprehensive research is\nneeded to introduce effective medicinal plants to treat diseases such as schistosomiasis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570163819666220228154752","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T05:54:38Z","timestamp":1646114078000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In Vivo<\/i> and <i>In Vitro<\/i> Anti-schistosomiasis Effect of Garlic: A Systematic\nReview"],"prefix":"10.2174","volume":"19","author":[{"given":"Pegah","family":"Shakib","sequence":"first","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Kalani","sequence":"additional","affiliation":[{"name":"Infectious\nDiseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Safar Maken","family":"Ali","sequence":"additional","affiliation":[{"name":"Veterinary Epidemiologist, Chief\nveterinary officer [CVO], Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Zebardastpour","sequence":"additional","affiliation":[{"name":"Lorestan Provincial Veterinary Service, Khorramabad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kobra","family":"Moradpour","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of\nInfectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University\nof Hong Kong, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahideh Heydari","family":"Nazarabad","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kourosh","family":"Cheraghipour","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ensci.2015.11.002","volume":"3","author":"Quansah E.","year":"2015","unstructured":"Quansah E.; Sarpong E.; Karikari T.K.; Disregard of neurological impairments associated with neglected tropical diseases in Africa. eNeurologicalSci 2015,3,11-14","journal-title":"eNeurologicalSci"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0169-4758(99)01589-6","volume":"16","author":"Hirst S.I.","year":"2000","unstructured":"Hirst S.I.; Stapley L.A.; Parasitology: the dawn of a new millennium. 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