{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:36:04Z","timestamp":1753889764178,"version":"3.41.2"},"reference-count":12,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDDT"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>5,11-Dihydroindolo [3, 2-\u00df]carbazole is one of the phytoconstituent of the\nArisaema genus, which might have various important biological activities. Recently, we have predicted\nthe antiviral potential of this phytoconstituent against the Japanese Encephalitis virus (JEV).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Thus, in the current study, the acute toxicity profile of 5, 11-dihydroindolo [3, 2-\u00df]carbazole\nas per OECD regulatory guidelines in female Wistar rats was evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We did not find any adverse effects, mortality, and altered behaviour in animals after administration\nof 5, 11-dihydroindolo [3, 2-\u00df] carbazole at a dose of 300 and 2000 mg\/Kg. Furthermore, no\nsignificant changes in physiological and haematological parameters were observed. The histopathological\nstudy of vital organs also showed no significant changes compared to the control.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Based on the findings of the current investigation, 5, 11-dihydroindolo [3, 2-\u00df]carbazole\nis a safe phytoconstituent of the Arisaema genus, which can be explored for various biological activities.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570163819666220429095155","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T12:44:06Z","timestamp":1652100246000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Toxicity Study of 5, 11-Dihydroindolo [3, 2-\u00df]carbazole as per\nOECD Regulatory Guidelines"],"prefix":"10.2174","volume":"20","author":[{"given":"Anoop","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Lucknow (UP)- 226002, India"},{"name":"Department of Pharmacology, Delhi Pharmaceutical Sciences &amp; Research\nUniversity (DPSRU), New Delhi, 110017, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navyashree V.","family":"Gowda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli),\nLucknow (UP), 226002, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailesh","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli),\nLucknow (UP), 226002, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1001\/archfami.7.6.523","volume":"7","author":"O\u2019Hara M.","year":"1998","unstructured":"O\u2019Hara M.; Kiefer D.; Farrell K.; Kemper K.; A review of 12 commonly used medicinal herbs. 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