{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:31:09Z","timestamp":1788067869572,"version":"build-2784847793"},"reference-count":50,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["COS"],"published-print":{"date-parts":[[2020,7,27]]},"abstract":"<jats:sec>\n<jats:title>Aims:<\/jats:title>\n<jats:p>A series of six 4-benzylidene-2-((1-phenyl-3,4-dihydro isoquinoline-2(1H)-yl)methyloxazol-\n5(4H)-one derivatives were synthesized by condensation of substituted aryl aldehydes with 2-(2-(1-phenyl-3,4-\ndihydro isoquinoline-2(1H)-acetamido)acetic acid in the presence of sodium acetate, acetic anhydride and zinc\noxide as catalysts.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Novel Synthesis of 4-Benzylidene-2-((1-phenyl-3,4-dihy droisoquinoline-2(1H)-yl)methyl)oxazol-\n5(4H)-one derivatives using 1,2,3,Tetrahydroisoquinoline and their antimicrobial activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The title compounds can be synthesized from 1,2,3,4-tetrahydroisoquinoline.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The target molecules, i.e., 4-benzylidene-2-((1-phenyl-3, 4-dihydro isoquinoline-2(1H)-yl) methyl)\noxazol-5(4H)-one derivatives (8a-8f) have been synthesized from 1,2,3,4-tetrahydroisoquinoline which was\nprepared from benzoic acid in few steps.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> All the six compounds were evaluated based on advanced spectral data (1H NMR, 13C NMR &amp;\nLCMS), and the chemical structures of all compounds were determined by elemental analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Antibacterial activity of the derivatives was examined for the synthesized compounds and results\nindicate that compound with bromine substitution has a good activity profile.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570179417666200415151228","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T17:51:06Z","timestamp":1586973066000},"page":"396-403","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Synthesis of 4-Benzylidene-2-((1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl)methyl) oxazol-5(4H)-one Derivatives Using 1,2,3,Tetrahydroisoquinoline and their Antimicrobial Activity"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-9930","authenticated-orcid":true,"given":"Nalla Krishna","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-6153","authenticated-orcid":true,"given":"Tentu Nageswara","family":"Rao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Changwon National University, Changwon, Gyeongnam, 641-773, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-0401","authenticated-orcid":true,"given":"Botsa","family":"Parvatamma","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Gayathri P.G Courses, Gotlam, Vizianagaram, AP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-0366","authenticated-orcid":true,"given":"Y.","family":"Prashanthi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mahatma Gandhi University, Nalgonda, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-9275","authenticated-orcid":true,"given":"Ravi Kumar","family":"Cheedarala","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Pohang University of Science and Technology (POSTECH), San 31 Hyojadong, Pohang, Kyeongbuk 790-784, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","author":"Gilchrist T.L.","year":"1997","unstructured":"Gilchrist T.L.;  Heterocyclic Chemistry 1997","journal-title":"Heterocyclic Chemistry"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","volume":"57","author":"Vitaku E.","year":"2014","unstructured":"Vitaku E.; Smith D.T.; Njardarson J.T.; Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. 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