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In the conventional method, 1,2,4-oxadiazoles were obtained in\ntwo steps. O-acylamidoximes obtained in the first step at room temperature were heated in toluene for an average\nof one hour to obtain 1,2,4-oxadiazoles. The yields varied from 70 to 96 %. 1,2,4-oxadiazoles were obtained under\nmicrowave irradiation in a single step in a 90-98 % yield at 160 \u00b0C in five minutes. 5-aminomethyl-3-aryl-1,2,4-\noxadiazoles (5a-j) were obtained by Gabriel amine synthesis in two steps from corresponding 5-chloromethyl-3-\naryl-1,2,4-oxadiazoles. Finally, twenty new urea (6a-j) and thiourea (7a-j) compounds bearing oxadiazole ring\nwere synthesized by reacting 5-aminomethyl-3-aryl-1,2,4-oxadiazoles with phenyl isocyanate and isothiocyanate\nin tetrahydrofuran (THF) at room temperature with average yields (40-70%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results and Discussions:<\/jats:title>\n<jats:p>An efficient and rapid method for the synthesis of 1,2,4-oxadiazoles from the\nreaction of amidoximes and acyl halides without using any coupling reagent under microwave irradiation has\nbeen developed, and twenty new urea\/thiourea compounds bearing 1,2,4-oxadiazole ring have been synthesized\nand characterized.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>We have synthesized a new series of urea\/thiourea derivatives bearing 1,2,4-oxadiazole ring. Also\nfacile synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from amidoximes and acyl chlorides under microwave\nirradiation was reported. The compounds were characterized using FTIR, 1H NMR, 13C NMR, and elemental\nanalysis techniques.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570179417666200417112106","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T07:13:42Z","timestamp":1587194022000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Potential Biologically Active Compounds: Synthesis and Characterization of Urea and Thiourea Derivativpes Bearing 1,2,4-oxadiazole Ring"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-1162","authenticated-orcid":true,"given":"Nevin Ar\u0131kan","family":"\u00d6lmez","sequence":"first","affiliation":[{"name":"Department of Chemistry, Bursa Uludag University, Bursa-16059, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-665X","authenticated-orcid":true,"given":"Faryal","family":"Waseer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bursa Uludag University, Bursa-16059, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S0014-827X(00)00099-9","volume":"55","author":"Leite A.C.L.","year":"2000","unstructured":"Leite A.C.L.; Vieira R.F.; de Wanderley A.G.; Afiatpour P.; Ximenes E.C.; Srivastava R.M.; de Oliveira C.F.; Medeiros M.V.; Antunes E.; Brondani D.J.; Brondani D.J.; Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics. 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