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Development of different IST based analogues acquired significant awareness because of its\npronounced therapeutic importance such as analgesic, anticancer, anti-inflammatory, antitubercular, antimicrobial,\nantifungal, antiviral (effective against SARS coronavirus 3C protease) and many other activities, and represents\nan important class of heterocyclic compounds that can be used as a precursor for the synthesis of many useful\ndrugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> Previously, many articles were reported on IST synthesis and its different pharmacological activities\nbut herein, we mentioned 59 different synthesis schemes of several IST derivatives\/hybrids derived from the substitution\nof the nitrogen, aromatic ring, the second and third position of IST along with most potent molecule\namong each of synthesized libraries with their structural activity relationship (SAR). Using these standardized\napproaches, several biologically important compounds were developed like sunitinib, nintedanib, indirubin, etc\nand several studies have been carried out nowadays to develop newer compounds having fewer side effects and\nalso overcome the problem of resistance.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>This report critically reviews the different strategies for the designs and synthesis of several IST\nbased compounds having different biological activities with SAR, which can favour further investigation and\nmodification for the development of new and more potent entities.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570179417666200924150907","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T04:59:29Z","timestamp":1601009969000},"page":"37-74","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Advances in Synthesis, Derivatization and Bioactivity of Isatin: A Review"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-2657","authenticated-orcid":true,"given":"Garima","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research (DIPSAR),Mehrauli-Badarpur Road, Sector 3, Pushp Vihar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharam Pal","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research (DIPSAR),Mehrauli-Badarpur Road, Sector 3, Pushp Vihar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraat","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research (DIPSAR),Mehrauli-Badarpur Road, Sector 3, Pushp Vihar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Bhutani","sequence":"additional","affiliation":[{"name":"School of Medical and Allied Sciences, G D Goenka University, Gurugram, Sohna, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Kapoor","sequence":"additional","affiliation":[{"name":"KIET Group of Institutions, Ghaziabad- Meerut Highway, NH-58, Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaik","family":"Khasimbi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Science and Research (DIPSAR),Mehrauli-Badarpur Road, Sector 3, Pushp Vihar, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","author":"Guo Y.","year":"1986","unstructured":"Guo Y.; Chen F.; Zhongcaoyao. 1986, 17. 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