{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:24:51Z","timestamp":1771824291255,"version":"3.50.1"},"reference-count":44,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["COS"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:sec>\n<jats:title>Aim and Objective:<\/jats:title>\n<jats:p>According to the literature survey, pyrazole is a unique template that is associated\nwith several biological activities. This article highlighted the research work of many researchers reported in the\nliterature for synthesis and different pharmacological activities of the pyrazole nucleus. In the present work, pyrazol-\n3-one 1 was reacted with cyanoacetic acid hydrazide and elemental sulfur to afford the corresponding\nthieno[3,2-c]pyrazol-6-carbohydrazide 3 derivatives. The latter compound reacted with some electrophilic reagents\nsuch as DMF-DMA, triethylorthoformate, arylidenemalononitriles and chalcones under neat conditions to\ngive substituted oxadiazole and pyrazole, respectively. The treatment of compound 3 with active methylene reagents\nsuch as acetylacetone, diethylmalonate, ethyl acetoacetate and ethyl cyanoacetate under suitable conditions\nafforded pyrazole derivatives 10, 11, 13, and 15, respectively. Novel pyrazolothienopyrimidine 27 and 30 were\nprepared from precursor 26 with carbon disulfide and triethylorthoformate, respectively. The chemical structures\nof the newly synthesized compounds were established by elemental and spectral analyses including IR, and 1HNMR\nin addition to 13C-NMR and mass spectra.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p> A novel substituted pyrazole, pyrimidine and pyrazolothienopyrimidine were obtained\nvia Gewald synthesis of thiophene and fused thiophene and Mannich reactions of 5-amino-3-phenyl-1Hthieno[\n3,2-c]pyrazole-6-carbohydrazide.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results and Discussion:<\/jats:title>\n<jats:p>A series of some newly azoles and azines were prepared via reaction of thieno[3,2-\nc]pyrazol-6-carbohydrazide derivative 3 as starting material with some electrophilic and nucleophilic reagents.\nThe structures of target compounds were established by elemental analyses and spectral data.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Pyrazole is a unique template that is associated with several biological activities. This article highlighted\nthe research work of many researchers reported in the literature for synthesis and different pharmacological\nactivities of the pyrazole nucleus. In the current investigation, we have developed new and efficient methods\nfor the synthesis of thieno[3,2-c]pyrazol-6-carbohydrazide derivatives. In addition, we have explored the preparative\npotential of these substances as intermediates for the synthesis of substituted pyrazoles and fused pyrazoles\n10-30, respectively.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570179417999200730215318","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T10:17:16Z","timestamp":1596622636000},"page":"661-670","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of Some New 1, 3, 4-Oxadiazole, Pyrazole, and Pyrimidine Bearing Thienopyrazole Moieties"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-1384","authenticated-orcid":true,"given":"Mohamed Ahmed Elian","family":"Sophy","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8667-7562","authenticated-orcid":true,"given":"Mohamed Ahmed Mahmoud","family":"Abdel Reheim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"414","volume":"9","author":"Rabie S.T.","year":"2013","unstructured":"Rabie S.T.; Abdelhalim M.M.; Mohamed N.R.; Synthesis of some novel pyrazole derivatives as potent antimicrobial agents. 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