{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:42:52Z","timestamp":1777052572086,"version":"3.51.4"},"reference-count":32,"publisher":"Bentham Science Publishers Ltd.","issue":"6","funder":[{"DOI":"10.13039\/501100006261","name":"Taif University Researchers Supporting Project, Saudi Arabia","doi-asserted-by":"publisher","award":["TURSP-2020\/81"],"award-info":[{"award-number":["TURSP-2020\/81"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["COS"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The current objective was to synthesize biologically active Isatin derivatives. For this purpose, six (06) chemical entities of Isatin derivatives such as 3a-3c and 4a-4c were syn-thesized from Isatin substrate.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The pure compounds were characterized with the help of 1H-NMR, FT-IR, EIMS spectro-scopic techniques. The synthesized amines 3a-3c and hydrazones 4a-4c were evaluated for their toxicity potential with the help of brine shrimp bioassay.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The obtained results revealed that 3c exhibited promising toxicity (LD50 = 1.03 \u00d7 10-5 M) against Artemia salina. The pure chemical entities such as compounds 3a-3c and 4a-4c were evalu-ated against four Gram-negative (E. coli, P. aeruginosa, S. typhi, S. flexneri) and two Gram-positive (B. subtilis, S. aureus) bacteriae. The compound 3a displayed significant activity against two bacte-rial strains; i.e. P. aeruginosa, S. typhi, compound 3c demonstrated significant activity against P. aeruginosa. Compound 4b was the most active against S. typhi, displaying a greater diameter of the growth of inhibition zone (GIZ) than the standard drug. Compound 4c exhibited significant activity against P. aeruginosa and S. typhi. Compounds 3a-3c and 4a-4c exhibited moderate to significant antibacterial activity against three out of five strains. Only Compound 3c revealed promising toxici-ty (LD50 = 1.03 \u00d7 10-5 M) against Artemia salina. Antifungal studies of the compounds 3a-3c and 4a-4c against six fungal cultures; T. longifusus, C. albicans, A. flavus, M. canis, F. solani, and C. glabrata. All the compounds were active against one or more pathogens having inhibition (10-90 %). Compound 3a exhibited significant inhibition i.e. 90 % against M. canis, 70 % against T. longifusus, Compound 4b further displayed significant inhibition (90 %) against A. flavus and thus proved to be the most active member of the series.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>All compounds showed better antibacterial, antifungal and cytotoxic activities, which may provide a ground to prepare enhanced molecules with much higher antibacterial activities.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570179419666220128091313","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T11:59:35Z","timestamp":1643371175000},"page":"748-756","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis of Isatin Derivatives Exhibiting Antibacterial, Antifungal and\nCytotoxic Activities"],"prefix":"10.2174","volume":"19","author":[{"given":"Muhammad","family":"Saleem","sequence":"first","affiliation":[{"name":"Department of Chemistry, Ghazi University, Dera Ghazi Khan-32200, Punjab, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maqbool","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Ghazi University, Dera Ghazi Khan-32200, Punjab, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana Farhat","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division\nof Science and Technology, University of Education, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afifa","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division\nof Science and Technology, University of Education, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shama","family":"Qaiser","sequence":"additional","affiliation":[{"name":"H.E.J. Research Institute of Chemistry, ICCBS, University\nof Karachi, Karachi-75270, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shah Iram","family":"Niaz","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences, Gomal University, Dera Ismail Khan-29220,\nKhyber Pakhtunkhwa, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Ali","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences, Gomal University, Dera Ismail Khan-29220,\nKhyber Pakhtunkhwa, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misbah","family":"Irshad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division\nof Science and Technology, University of Education, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Division\nof Science and Technology, University of Education, Lahore, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"A. Abubshait","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science and Basic & Applied Scientific Research Center,\nImam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Damman, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haya","family":"A. Abubshait","sequence":"additional","affiliation":[{"name":"Institute for Research and\nMedical Consultation (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Damman, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Research Center for Advanced Materials Science, King Khalid University, P.O. 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