{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:53:02Z","timestamp":1767181982939,"version":"3.37.3"},"reference-count":41,"publisher":"Bentham Science Publishers Ltd.","issue":"4","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100007174","name":"Council for Scientific and Industrial Research","doi-asserted-by":"publisher","award":["09\/892(0002)\/2015-EMR-1"],"award-info":[{"award-number":["09\/892(0002)\/2015-EMR-1"]}],"id":[{"id":"10.13039\/501100007174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPR"],"published-print":{"date-parts":[[2019,12,30]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Congenital Pouch Colon (CPC) is an anorectal anomaly with an incidence of 3.5:1 in males and females, respectively. We have earlier reported CPC to be quite prevalent in north Indian tertiary care centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>n this article, we deliberate on the possible causes associated with CPC bringing the manifestation of the disease. In addition, we throw insights on the effective role of this congenital anomaly in Colon and provide systems genomic evaluation by comparing our recent analysis to that of Colon and Ileum based on Next-Generation Sequencing (NGS) studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>In this commentary article, we argue that a host of epigenetic factors could be the reason why the disease is manifested in colon alone. We further hypothesize on the few unmet challenges linking epigenetics to understand the genetic variants.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1573396315666190829155930","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T13:35:26Z","timestamp":1567172126000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is Pouch Specific to Colon and Not Ileum?"],"prefix":"10.2174","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-1170","authenticated-orcid":true,"given":"Sonal","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur 302001, RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Basic Sciences, Manipal University Jaipur, Jaipur 303007, RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, IIS (Deemed to be University), Mansarovar, Jaipur 302020, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Nunia","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Rajasthan, Jaipur 302004, RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amulya K","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Imperial College London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Simlot","sequence":"additional","affiliation":[{"name":"Department of Obstretrics and Gynaecology, SMS Medical College, JLN Marg, Jaipur 302004 RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanker Lal","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Amity University Rajasthan, Jaipur 303002 RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashanth","family":"Suravajhala","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur 302001, RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna Mohan","family":"Medicherla","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Jaipur 302001, RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, SMS Medical College, JLN Marg, Jaipur 302004 RJ, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.4103\/jiaps.JIAPS_5_17","volume":"22","author":"Chadha R.","year":"2017","unstructured":"Chadha R.; Khan N.A.; Congenital pouch colon. 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