{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:36:49Z","timestamp":1771303009350,"version":"3.50.1"},"reference-count":39,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPR"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone disorder mostly\naffecting children and adolescents. Although it is considered a rare disease, CNO is likely to be the\nsingle most common autoinflammatory bone disease in childhood, underdiagnosed and underreported\ndue to a lack of awareness of the condition in both medics and patients and the absence of\nvalidated diagnostic criteria. The exact underlying pathogenesis of CNO remains unknown, making\ntargeted treatment difficult. This issue is exacerbated by the lack of any randomised control trials,\nmeaning that treatment strategies are based solely on retrospective reviews and case series.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>This review summarises the current concepts in pathophysiology, the clinical features that help differentiate\nimportant differential diagnoses, and an approach to investigating and managing children\nwith CNO. Ultimately, the timely and thorough investigation of children and young people with\nCNO is vitally important to exclude important mimics and initiate appropriate management that can\nprevent the complications of persistent inflammatory bone disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573396319666221027123723","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T07:22:33Z","timestamp":1666941753000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic Non-bacterial Osteomyelitis (CNO) In Childhood: A Review"],"prefix":"10.2174","volume":"20","author":[{"given":"Fiona","family":"Price-Kuehne","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Armon","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3899\/jrheum.161255","volume":"44","author":"Schnabel A.","year":"2017","unstructured":"Schnabel A.; Range U.; Hahn G.; Berner R.; Hedrich C.M.; Treatment response and longterm outcomes in children with chronic nonbacterial osteomyelitis. 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