{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:22:08Z","timestamp":1747207328543,"version":"3.40.5"},"reference-count":88,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPR"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Irritable bowel syndrome (IBS) is a disorder that causes stomach pain in children and adolescents. It may also impact one's quality of life. IBS is linked to gastrointestinal issues such as diarrhoea and constipation. Despite the identification of several potential pathophysi-ological pathways, the aetiology of IBS remained unknown<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of this paper is to discuss the diagnosis, pathogenesis, case studies and treatment of Irritable bowel syndrome in children and adolescents.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This systematic review covered relevant papers from the previous ten years that were accessible in Science Direct, Elsevier, NCBI, and Web of Science related to the pathophysiology and function of pharmacological drugs such as antidepressants, antispasmodics, prokinetics, and antibiotics in children with irritable bowel syndrome.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>those have been demonstrated to be effective. This article presents case studies including 50-59 children, which demonstrate a favourable acceptable impact that is more effective than a pla-cebo in terms of reducing symptoms and improving the overall quality of life in children who have irritable bowel syndrome. Furthermore, the majority of the pathophysiological explanations and treatment options discussed are based on adult studies. These major issues arose when treating paediatric IBS, and they must be addressed in order to properly treat children with IBS. Trials that focus on many combinations of pharmacological and non-pharmacological therapies seem to be more helpful.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Discussion:<\/jats:title>\n<jats:p>In recent years, a number of systematic reviews have been conducted to evaluate the efficacy of medication treatments in children for IBS; however, the dependability of these systemat-ic reviews needs to be further investigated owing to the various experimental designs and levels of evidence used. This article highlights paediatric therapy options, including pharmaceutical medica-tions such as antidepressants, antispasmodics, prokinetics, and antibiotics. The goal is to alleviate IBS symptoms while also enhancing the quality of life for children with this illness.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573396319666221128094843","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T05:53:42Z","timestamp":1669701222000},"page":"166-177","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Children and Adolescents with Irritable Bowel Syndrome: Treatment and\nManagement"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-1382","authenticated-orcid":true,"given":"Ankita","family":"Wal","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Pranveer Singh Institute of Technology, Nh2 Kanpur Agra Highway Bhaunti, Kanpur, UP, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6342-6290","authenticated-orcid":true,"given":"Pranay","family":"Wal","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pranveer Singh Institute of Technology, Nh2 Kanpur Agra Highway Bhaunti, Kanpur, UP, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6671-1284","authenticated-orcid":true,"given":"Neha","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pranveer Singh Institute of Technology, Nh2 Kanpur Agra Highway Bhaunti, Kanpur, UP, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-1364","authenticated-orcid":true,"given":"Shiv Shanker","family":"Pandey","sequence":"additional","affiliation":[{"name":"Tahira Institute of Medical Sciences, Gida Gorakhpur, UP, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-730X","authenticated-orcid":true,"given":"Karthickeyan","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Institute of Science Technology &amp; Advanced Studies Pallavaram, Chennai, 600117, Tamil Nadu, 600117, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithun","family":"Bhowmick","sequence":"additional","affiliation":[{"name":"D101 Shikshak Niketan, Campus of Bengal\nCollege of Pharmaceutical Sciences and Research, Bidhananagar Durgapur, West Bengal, 713212, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/jcm6110099","volume":"6","author":"Lacy B.","year":"2017","unstructured":"Lacy B.; Patel N.; Rome criteria and a diagnostic approach to irritable bowel syndrome. 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