{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T14:17:38Z","timestamp":1794406658543,"version":"4.9.0"},"reference-count":322,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CPR"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Infectious mononucleosis is common among adolescents and young adults.\nAlthough the majority of cases resolve spontaneously, life-threatening manifestations, and compli-\ncations have been recognised.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The purpose of this article is to familiarize clinicians with the clinical manifestations,\nevaluation, diagnosis, and management of infectious mononucleosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A search was conducted in October 2022 in PubMed Clinical Queries using the key terms\n\"infectious mononucleosis\" OR \u201cEpstein-Barr virus\u201d OR \u201cEBV\u201d. The search strategy included all\nclinical trials, observational studies, and reviews published within the past 10 years. Only papers\npublished in the English literature were included in this review. The information retrieved from the\naforementioned search was used in the compilation of the present article.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Infectious mononucleosis, caused by Epstein-Barr virus, most commonly affects adoles-\ncents and adults aged 15 to 24 years. Epstein-Barr virus is transmitted primarily in saliva. Infectious\nmononucleosis is characterized by a triad of fever, tonsillar pharyngitis, and lymphadenopathy. Fa-\ntigue may be profound but tends to resolve within three months. Periorbital and\/or palpebral edema,\ntypically bilateral, occurs in one-third of patients. Splenomegaly and hepatomegaly occur in approx-\nimately 50% and 10% of cases, respectively. A skin rash, which is usually widely scattered, ery-\nthematous, and maculopapular, occurs in approximately 10 to 45% of cases. Peripheral blood leu-\nkocytosis is observed in most patients; lymphocytes make up at least 50% of the white blood cell\ndifferential count. Atypical lymphocytes constitute more than 10% of the total lymphocyte count.\nThe classic test for infectious mononucleosis is the demonstration of heterophile antibodies. The monospot test is the most widely used method to detect the serum heterophile antibodies of infectious mononucleosis. When confirmation of the diagnosis of infectious mononucleosis is required in\npatients with mononucleosis-like illness and a negative mono-spot test, serologic testing for anti-\nbodies to viral capsid antigens is recommended. Infectious mononucleosis is a risk factor for chronic fatigue syndrome. Spontaneous splenic rupture occurs in 0.1 to 0.5% of patients with infectious\nmononucleosis and is potentially life-threatening. Treatment is mainly supportive. Reduction of activity and bed rest as tolerated are recommended. Patients should be advised to avoid contact sports\nor strenuous exercise for 8 weeks or while splenomegaly is still present. Most patients have an uneventful recovery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Infectious mononucleosis is generally a benign and self-limited disease. Prompt diag-\nnosis is essential to avoid unnecessary investigations and treatments and to minimize complications.\nSplenic rupture is the most feared complication. As avoiding exposure to EBV is almost impossible,\nthe most effective way to prevent EBV infection and infectious mononucleosis is the development\nof an effective, safe, and affordable EBV vaccine that can confer life-long immunity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573396320666230801091558","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T12:29:05Z","timestamp":1690892945000},"page":"305-322","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Infectious Mononucleosis: An Updated Review"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2254-6971","authenticated-orcid":true,"given":"Alexander K.C.","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The University of Calgary, Alberta Children\u2019s Hospital, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-3369","authenticated-orcid":true,"given":"Joseph M.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Dermatology and Skin Sciences, \nUniversity of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-8968","authenticated-orcid":true,"given":"Benjamin","family":"Barankin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Toronto Dermatology Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1186\/s12889-020-09049-x","volume":"20","author":"Kuri A.","year":"2020","unstructured":"Kuri A.; Jacobs B.M.; Vickaryous N.; Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United King-dom. 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