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This retrospective study was designed to investigate\nthe fetal and maternal outcomes of Iranian women with SLE.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Clinical and laboratory records of 60 pregnancies in 55 SLE patients who attended Hafez\nhospital, a tertiary referral center for high risk pregnancies and SLE patients affiliated with Shiraz\nUniversity of Medical Science, were reviewed during April 2012 and March 2016.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The mean age of the patients was 29.28\u00b14.6 years and mean disease duration was 5.09\u00b14.2\nyears. Live birth rate was 83.3% after exclusion of elective abortions. There were 50 live births, 3\nneonatal deaths, 3 spontaneous abortions and 7 stillbirths. 9 (15%) women developed preeclampsia\nand there was 1 (1.6%) case of HELLP syndrome. Lupus flares occurred in 27 (45%) patients during\npregnancy. Preterm delivery occurred in 11.6% of pregnancies. Skin and joints were the most\nfrequently affected organs. Patients with previous lupus nephritis (n=18) were associated with a\nhigher risk of maternal complication, but fetal outcomes were similar in both groups. Cesarean rate\nwas about 66%, mostly related to fetal indications (50%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Pregnancies in most women with pre-existing SLE can now be managed with successful\nresults although presence of previous lupus nephritis is still a major risk factor for adverse maternal\noutcomes. In our study, fetal outcome was not different between patients with lupus nephritis\ncompared with the patients without nephritis who were under treatments. Hence, to achieve favorable\nlong-term results, we recommend regular multispecialty treatment approaches and progestational\ncounseling for women with SLE.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573397115666190125162248","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T02:51:16Z","timestamp":1548643876000},"page":"321-328","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal and Fetal Outcomes in Iranian Patients with Systemic Lupus Erythematosus: A Five-Year Retrospective Study of 60 Pregnancies"],"prefix":"10.2174","volume":"15","author":[{"given":"P.","family":"Karimzadeh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shenavandeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Asadi","sequence":"additional","affiliation":[{"name":"Maternal-fetal medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"330","volume":"6","author":"Cojocaru M.","year":"2011","unstructured":"Cojocaru M.; Cojocaru I.M.; Silosi I.; Vrabie C.D.; Manifestations of systemic lupus erythematosus. 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