{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:09:02Z","timestamp":1793686142765,"version":"4.5.1"},"reference-count":21,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.AJUMS.REC.1396.646"],"award-info":[{"award-number":["IR.AJUMS.REC.1396.646"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2020,9,22]]},"abstract":"<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>The aim of this study was to evaluate the relationship between Interleukin-6 (IL-6)\nserum level and the severity and activity of Rheumatoid Arthritis (RA).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In this cross-sectional study, 120 RA patients referred to the rheumatology clinic, the patients\nwere diagnosed by rheumatologists according to ACR \/ EULAR 2010 criteria. Based on\nDAS28 score the patients were divided into 4 groups: Remission, Mild, Moderate and Severe. Each\ngroup contained 30 patients. Serum levels of Erythrocyte Sedimentation Rate (ESR), C-Reactive\nProtein (CRP), anti-Cyclic Citrullinated Peptide (anti-CCP) and Rheumatoid Factor (RF) and serum\nlevels of IL-6, were measured. The relationship between these factors was measured and compared\nto the relationship between IL-6 and these factors, and the activity of the disease was evaluated\nbased on DAS-28.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>This study showed that the serum level of IL-6 has a significant relationship with RA activity\naccording to DAS-28 (P value &lt;0.001). There is also a significant relationship between the\nESR level, the number of painful joints, and the number of swollen joints, and the severity of the\ndisease based on VAS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> Generally the findings of this study indicate that serum level of IL-6 plays an important\nrole in the severity and activity of RA disease and can be considered as a determining factor in\nevaluating the severity of RA in RA patients and it is a good guide for a step up or down of treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573397115666190206144223","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T13:44:55Z","timestamp":1581947095000},"page":"249-255","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluating the Relationship Between Serum Level of Interleukin-6 and Rheumatoid Arthritis Severity and Disease Activity"],"prefix":"10.2174","volume":"16","author":[{"given":"Elham","family":"Rajaei","sequence":"first","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Mowla","sequence":"additional","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qodratollah","family":"Hayati","sequence":"additional","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Dargahi-Malamir","sequence":"additional","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Hesam","sequence":"additional","affiliation":[{"name":"Department of Statistics and Epidemiology School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab Deris","family":"Zayeri","sequence":"additional","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11515-017-1452-4","volume":"12","author":"Mowla K.","year":"2017","unstructured":"Mowla K.; Saki M.A.; Jalali M.T.; Zayeri Z.D.; How to manage rheumatoid arthritis according to classic biomarkers and polymorphisms? 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