{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:51:05Z","timestamp":1775915465890,"version":"3.50.1"},"reference-count":31,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2020,3,5]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p> Osteoporosis is a common comorbidity in Rheumatoid Arthritis (RA) patients\nand can result in estimated double risk of pathological fractures. Bone Mineral Density\n(BMD) is known to decrease with RA because of mechanisms incorporating traditional as well as\ndisease-specific causes. With the advent of newer disease-modifying antirheumatic agents and bone\nprotection medications, it is becoming important to identify those individuals who are at increased\nrisk of developing osteoporosis among RA patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title> Aim:<\/jats:title>\n<jats:p> In the current study, we aim to evaluate a multitude of factors including focal erosions on radiographs\nof hands or feet that can predict osteoporosis in RA patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>After obtaining IRB approval, 26 patients (20 females &amp; 6 males) with a median age of\n62 years (95% CI: 57.4 - 66.0) were retrospectively identified from a Rheumatology clinic database\nwith an established diagnosis of RA but not taking osteoporosis medications. A detailed assessment\nwas accomplished including evaluating a number of disease-specific variables, hands\/feet radiographs\nand Dual-energy X-ray Absorptiometry (DXA).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The total hip BMD was lower in RA patients with radiographic erosions (0.862 g\/cm2 \u00b1\n0.17) compared to those patients without erosions (1.011 g\/cm2 \u00b1 0.13). On univariate logistic regression,\nthe presence of radiographic erosions predicted osteoporosis of the hip (p = 0.04). ROC\ncurve demonstrated satisfactory performance of erosions in predicting WHO-defined osteoporosis\nor osteopenia at the hip (AUC = 0.732).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> RA patients who show radiographic erosions are more likely to develop hip osteoporosis\nthat may require further intervention.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573397115666190716120127","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T09:00:57Z","timestamp":1563872457000},"page":"74-78","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Utility of Radiographic Focal Erosions of Hands or Feet in Predicting DXA-defined Osteoporosis of the Hip in Patients with Rheumatoid Arthritis"],"prefix":"10.2174","volume":"16","author":[{"given":"Mohsen H.","family":"Elshahaly","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled A.","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5114\/reum.2016.58759","volume":"54","author":"W\u0119gierska M.","year":"2016","unstructured":"W\u0119gierska M.; Dura M.; Blumfield E.; \u017buchowski P.; Waszczak M.; Jeka S.; Osteoporosis diagnostics in patients with rheumatoid arthritis. 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