{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:13:58Z","timestamp":1787066038154,"version":"build-2736575974"},"reference-count":31,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2020,5,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Behcet's disease is a potentially life threatening autoimmune disease with\nrecurrent ulcers and unknown pathogenesis. Gender and human leukocyte antigen-B51 seem to\nhave an effective role in the clinical features of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study is to evaluate the frequency of HLA-B5, 7, 8, 27 and 51 in beh\u00e7et's\ndisease in southwestern Iranian patients who visited the rheumatology clinic and to find the association\nbetween these HLA types and the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>63 patients with behcet's disease participated in this study and peripheral blood samples\nwere collected from them. The expression of each HLA antigen was evaluated by standard lymphocytotoxicity\ntechnique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared to other studied antigens, the expression of HLA-B5 and HLA-B51 was more\nprevalent among our patients. According to the results, 25% and 21% of patients were positive for\nHLA-B5 and HLA-B51, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>HLA-B5 and HLA-B51 are dominant positive HLA antigens among behcet's disease\npatients in the southwest of Iran; however, we cannot conclude that these antigens are valuable diagnostic\nor prognostic biomarkers due to our study limitations. We suggest studying the association\nbetween HLA-B antigens and inflammation severity in patients to determine the possible prognostic\nvalue of HLA-B antigens in Iranian population in the southwest and this region needs more\nstudies in HLA subject among BD patients because of the frequency of BD to evaluate the value of\nHLA typing in BD prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1573397115666190918153721","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T08:47:16Z","timestamp":1568796436000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dose HLA-B5, 7, 8, 27, and 51 Antigens Associated to Behcet's disease? A Study in Southwestern Iran"],"prefix":"10.2174","volume":"16","author":[{"given":"Elham","family":"Rajaei","sequence":"first","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad T.","family":"Jalali","sequence":"additional","affiliation":[{"name":"Hyperlipidemia Research Center, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed M. Sadegh","family":"Pezeshki","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Rezaeeyan","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Maniati","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Elyasi","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab D.","family":"Zayeri","sequence":"additional","affiliation":[{"name":"Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.2217\/pgs-2015-0004","volume":"17","author":"Gheita T.A.","year":"2016","unstructured":"Gheita T.A.; Gheita H.A.; Kenawy S.A.; The potential of genetically guided treatment in Beh\u00e7et\u2019s disease. 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