{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:00:34Z","timestamp":1783792834575,"version":"3.55.0"},"reference-count":19,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2020,5,11]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>Rheumatoid arthritis (RA) is biologically marked by a positive serum rate\nof rheumatoid factor (RA) and\/or anti-citrullinated protein antibodies (ACPA). Nevertheless, 20%\nof RA cases remain seronegative.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> The main purpose of this study, is to bring out the clinical, biological, imaging, therapeutic,\nand evolutionary distinctions between seropositive RA and seronegative one.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This is an observational cross-sectional study that involves patients with RA admitted in\nthe rheumatology department, from the period between January 2012 and January 2018. RA seronegativity\nis described as the absence of both RF and ACPA, while seropositivity is recognized by\nthe presence of at least one of the two antibodies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> 294 patients were included, of which 90% were seropositive and 10% seronegative. Therefore,\nRA in this study is seropositive most often. The bivariate analysis underscored plenty of differences,\nstatistically notable, according to the RA immune status. In fact, patients with seropositive\nRA had more synovitis (p=0.049), more deformities (p=0.01), and more bone destruction on radiographs\n(p=0.04). Furthermore, RA in this Moroccan study was quite severe (p=0.006) and got more\ncomplicated by systemic manifestations (p=0.02). Whereas, no distinction was brought up between\nthe two groups, concerning the use of biotherapy. As for the multivariate study, seropositive RA in\nthese patients, had greater severity (p=0.009, OR=4.53) and was more deforming (p=0.03\nOR=2.45).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>RA in our Moroccan context is dominated by the seropositive form. This seropositivity\nis often coupled with clinical severity and joint destruction, resulting in more deformities.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573397115666191018115337","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T06:39:55Z","timestamp":1572244795000},"page":"143-148","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rheumatoid Arthritis: Seropositivity versus Seronegativity; A Comparative Cross-sectional Study Arising from Moroccan Context"],"prefix":"10.2174","volume":"16","author":[{"given":"Ksir","family":"Salma","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akasbi","family":"Nessrine","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efemba","family":"Krystel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El Kinany","family":"Khaoula","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naji","family":"Noura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elkohen","family":"Khadija","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harzy","family":"Taoufik","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hassan II University Medical Center, Faculty of Medicine, University Sidi Mohammed Ben Abdellah, Fes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1136\/ard.2006.051391","volume":"65","author":"Avouac J.","year":"2006","unstructured":"Avouac J.; Gossec L.; Dougados M.; Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. 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