{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:22:13Z","timestamp":1747207333447,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2020,12,24]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Sarcoidosis is a systemic inflammatory disease of unknown etiology that\ncan affect virtually any organ. L\u00f6fgren syndrome, characterized by erythema nodosum, hilar lymphadenopathy,\nfever and polyarthritis, represents only 20-30% of the cases of sarcoidosis. Only 2-\n10% of the cases feature hypercalcemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case:<\/jats:title>\n<jats:p>The case of a 42-year-old Hispanic woman with a history of erythema nodosum and three\nweeks of nausea, emesis, constipation, asthenia, adynamia, polydipsia, and somnolence, concomitant\nwith hypercalcemia, but normal parathyroid hormone (PTH) and 25-hydroxyvitamin D has\nbeen presented. The initial diagnostic approach was based upon the suspicion of multiple myeloma\nor bone metastases; however, further findings of bilateral hilar lymphadenopathy, elevated serum\nangiotensin-converting enzyme (ACE) and a right inguinal lymphadenomegaly suggested an alternate\ndiagnosis. Biopsy of the latter supported sarcoidosis as the diagnosis. She was successfully\ntreated in the hospital with zoledronic acid and as an outpatient with immunosuppressive therapy.\nPersistence of a previously undisclosed symptom of oligomenorrhea led to the detection of hyperprolactinemia\nsecondary to hypophyseal infiltration, refractory to immunosuppressive therapy but\nwith an adequate response to cabergoline.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> This case strays from L\u00f6fgren Syndrome\u2019s expected behavior, presenting a more progressive,\nmultisystemic disease. This case report was written in adhThis case strays from L\u00f6fgren Syndrome\u2019s expected behavior, presenting a more progressive,\nmultisystemic disease. This case report was written in adherence to the CARE guidelines\nof 2013 to include information in it.erence to the CARE guidelines\nof 2013 to include information in it.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573397115666191021154628","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T14:45:54Z","timestamp":1571841954000},"page":"337-342","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["L\u00f6fgren Syndrome with Hypercalcemia and Neuroendocrinological Involvement: A Case Report"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-4897","authenticated-orcid":true,"given":"Daniel","family":"Almaguer-Morales","sequence":"first","affiliation":[{"name":"Escuela de Medicina Ignacio Santos, Instituto Tecnol, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Eugenio","family":"Hinojosa-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina Ignacio Santos, Instituto Tecnol, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Garza-Alpirez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina Ignacio Santos, Instituto Tecnol, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Rheumatology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/175976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/175976\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/175976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T10:33:35Z","timestamp":1609151615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/175976\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,24]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12,24]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573397115666191021154628","relation":{},"ISSN":["1573-3971"],"issn-type":[{"type":"print","value":"1573-3971"}],"subject":[],"published":{"date-parts":[[2020,12,24]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2017-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}