{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T01:51:02Z","timestamp":1751421062630,"version":"3.37.3"},"reference-count":22,"publisher":"Bentham Science Publishers Ltd.","issue":"4","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974250"],"award-info":[{"award-number":["81974250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"Post- Doctorate Research Project, West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2018HXBH017"],"award-info":[{"award-number":["2018HXBH017"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2023,8,3]]},"abstract":"<jats:sec>\n<jats:title>Background::<\/jats:title>\n<jats:p>Polymyositis (PM) and dermatomyositis (DM) are non-suppurative and autoimmune inflammatory diseases of striated muscle. Interstitial lung disease (ILD) is a group of heterogeneous diseases that mainly involve the pulmonary interstitium, alveoli, and\/or bronchioles, also known as diffuse parenchymal lung disease (DPLD). A significant cause of death in persons with polymyositis (PM) and dermatomyositis (DM) is concurrent interstitial lung disease (ILD). However, research on the clinical characteristics and associated influencing factors of PM\/DM combined with ILD (PM\/DM-ILD) is currently scarce in China.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective::<\/jats:title>\n<jats:p>The study aimed to probe the clinical features and risk factors of PM\/DM-ILD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods::<\/jats:title>\n<jats:p>The data of 130 patients with PM\/DM were gathered. General medical status, clinical symptoms, laboratory parameters, high-resolution CT, therapeutic outcomes, and prognoses were retrospectively reviewed in patients with PM\/DM with (ILD group) and without (NILD) ILD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results::<\/jats:title>\n<jats:p>The age of the ILD group (n=65) was more than the NILD group (n=65), and the differ-ence was statistically significant; there were no significant between-group variations in the PM\/DM ratio, sex, or duration of the disease. The initial symptoms were arthritis and respiratory symptoms in the ILD group, and myasthenia symptoms in the NILD group. Incidences of Raynaud\u2019s phenom-enon, dry cough, expectoration, dyspnea on exertion, arthritis, fever, total globulin (GLOB), eryth-rocyte sedimentation rate (ESR), and anti-Jo-1 antibody rate were higher for ILD; however, albumin (ALB), creatine kinase aspartate aminotransferase activity ratio (CK\/AST) and CK levels were sig-nificantly lower in the ILD group. Bivariate logistic regression analysis showed age, dry cough, ar-thritis, dyspnea on exertion, anti-Jo-1 antibody, and elevated GLOB to be independent risk factors for ILD among patients with PM\/DM.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion::<\/jats:title>\n<jats:p>Advanced age, dry cough, arthritis, dyspnea on exertion, anti-Jo-1 antibody positivity, and elevated GLOB level are risk factors for PM\/DM-ILD. This information could be utilized to carefully monitor changing lung function in these patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573397119666230330082452","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T04:03:36Z","timestamp":1680494616000},"page":"455-462","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Risk Factors of Polymyositis and Dermatomyositis\nCombined with Interstitial Lung Disease in Patients Residing in\nthe Northeast Sichuan Province of China"],"prefix":"10.2174","volume":"19","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan-Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-Ni","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Lin","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Qing","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1183\/16000617.00002015","volume":"24","author":"Lega J.C.","year":"2015","unstructured":"Lega J.C.; Reynaud Q.; Belot A.; Fabien N.; Durieu I.; Cottin V.; Idiopathic inflammatory myopathies and the lung. 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