{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:01:38Z","timestamp":1740142898651,"version":"3.37.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","funder":[{"DOI":"10.13039\/501100004035","name":"Jordan University of Science and Technology","doi-asserted-by":"publisher","award":["20180224"],"award-info":[{"award-number":["20180224"]}],"id":[{"id":"10.13039\/501100004035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDR"],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Vitamin D is increasingly investigated as having a role in Type 2 Diabetes\nMellitus (T2DM) and its cardiovascular and renal complications.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aimed to investigate the association between 25-hydroxyvitamin D (25-OHD) and\nbiomarkers of cardiovascular and renal complications, including cystatin-C.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This cross-sectional study involved 117 participants with T2DM that was not complicated\nwith cardiovascular or renal diseases except hypertension. 25-OHD was measured by electrochemiluminescence\nimmunoassay, while cystatin-C was measured by enzyme-linked-immunosorbent-assay. Other\nbiomarkers, including lipids, creatinine, urea and glycemic measures, were determined by the routine\nbiochemistry assays.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The prevalence of vitamin D deficiency was 74.36%. There was no significant difference in\ncardiovascular and renal biomarkers, including glucose, HbA1c, lipids, urea, creatinine and cystatin-C\nbetween participants with adequate and deficient vitamin D (p-values&gt;0.05). Participants with adequate\nvitamin D were older in age, more obese and having lower eGFR (p-values&lt;0.05). 25-OHD was weakly\ncorrelated with age, duration of DM, urea, creatinine and inversely correlated with eGFR (rvalues&lt;\n0.32, p-values&lt;0.05). Although creatinine and cystatin-C were directly correlated (r=0.42, pvalue&lt;\n0.001), cystatin-C and 25-OHD were not correlated (p-value&gt;0.05). Hypertensive participants\nwere more obese, having a longer duration of DM and higher urea and cystatin-C compared to nonhypertensive\nparticipants (p-values&lt;0.05). Binary logistic regression analysis revealed that hypertension\ncould be predicted from increased BMI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>25-OHD was not found to be correlated with cardiovascular risk biomarkers, but it was\ncorrelated with renal biomarkers, including urea, creatinine and eGFR. Cystatin-C and 25-OHD were\nnot observed to be correlated to each other, but both were correlated to renal function. Obesity was a\nsignificant predictor of hypertension.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573399816666200516174352","type":"journal-article","created":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T04:44:35Z","timestamp":1589690675000},"page":"81-90","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Prevalence of Vitamin D Deficiency and Correlation with Cystatin-C and Other Cardiovascular and Renal Risk Biomarkers in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9490-0979","authenticated-orcid":true,"given":"Mohammad J.","family":"Alkhatatbeh","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajedah A.","family":"Smadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid K.","family":"Abdul-Razzak","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesreen A.","family":"Saadeh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Diabetes Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/182022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/182022\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/182022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T06:22:02Z","timestamp":1609741322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/182022\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573399816666200516174352","relation":{},"ISSN":["1573-3998"],"issn-type":[{"type":"print","value":"1573-3998"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}