{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:15:51Z","timestamp":1761156951387,"version":"3.40.5"},"reference-count":32,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDR"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Diabetes mellitus is the 7th leading cause of death worldwide. Diabetes can affect the organ\nsystems and lead to serious complications, majorly categorized as macrovascular complications, microvascular\ncomplications, and diabetic wounds. Foot ulcer develops in 15-25% diabetic patients. In\ndiabetic wound, there is an impairment in growth factor, neuropeptide, matrix metalloproteinases, angiogenesis,\nand immune system. Many approaches are being experimented to manage this major complication\nof diabetic foot, but unfortunately with lower success rate. Stem cell is an upcoming field which\nis being explored in the world of diabetes. Hence, this review is designed to understand the basic pathogenesis\nand complications of types of diabetes and the role of stem cells in a diabetic wound and the\nbenefits related to it.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573399816666200716200450","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T06:29:37Z","timestamp":1594967377000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stem Cells: A Golden Therapy for Diabetic Wounds"],"prefix":"10.2174","volume":"17","author":[{"given":"Shubhangi","family":"Buchade","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Bhonde","sequence":"additional","affiliation":[{"name":"Dr. D.Y. Patil Vidyapeeth, Pune,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heena","family":"Kazi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6069-7354","authenticated-orcid":true,"given":"Shivani","family":"Sainani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketki","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pune,India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"46","volume":"4","author":"State A","unstructured":"State A; Biology E;  The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus 2013 ,4(4),46-57","journal-title":"The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus 2013"},{"key":"ref=2","author":"Mohan H.","year":"2018","unstructured":"Mohan H.;  Textbook of pathology Jaypee Brothers 2018","journal-title":"Textbook of pathology Jaypee Brothers"},{"key":"ref=3","unstructured":"Diabetes. Newsroom. World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes"},{"key":"ref=4","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.10.008","author":"Tan S.Y.","year":"2018","unstructured":"Tan S.Y.; Ling J.; Wong M.; Sim Y.J.; Wong S.S.; Abdelgadir S.; Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes Metab Syndr 2018","journal-title":"Diabetes Metab Syndr"},{"key":"ref=5","first-page":"1","author":"Gharravi A.M.","year":"2017","unstructured":"Gharravi A.M.; Jafar A.; Ebrahimi M.; Mahmodi A.; Pourhashemi E.; Haseli N.;  SC Connections E 2017,1-28","journal-title":"SC Connections E"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2337\/diaclin.26.2.77","volume":"26","author":"Fowler M.J.","year":"2008","unstructured":"Fowler M.J.; Microvascular and Macrovascular Complications of Diabetes. Clin Dia 2008,26(2),77-82","journal-title":"Clin Dia"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2337\/diacare.29.s1.06.s43","volume":"29","year":"2006","unstructured":"Diagnosis and classification of diabetes mellitus. Diabetes Care American Diabetes Association2006,29(Suppl. 1),S43-S48","journal-title":"Diabetes Care"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.2522\/ptj.20080008","volume":"88","author":"Cade W.T.","year":"2008","unstructured":"Cade W.T.; Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther 2008,88(11),1322-1335","journal-title":"Phys Ther"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physrev.00045.2011","volume":"93","author":"Forbes J.M.","year":"2013","unstructured":"Forbes J.M.; Cooper M.E.; Mechanisms of diabetic complications. Physiol Rev 2013,93(1),137-188","journal-title":"Physiol Rev"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3923\/jbs.2010.411.423","volume":"10","author":"Behnam-Rassouli M.","year":"2010","unstructured":"Behnam-Rassouli M.; Ghayour M.B.; Ghayour N.; Microvascular complications of diabetes. J Biol Sci 2010,10(5),411-423","journal-title":"J Biol Sci"},{"key":"ref=11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2016.12.022","author":"Khalil H.","year":"2016","unstructured":"Khalil H.; Diabetes","journal-title":"Diabetes Metab Syndr"},{"key":"ref=12","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/385641","author":"Tsourdi E.","year":"2013","unstructured":"Tsourdi E.; Barthel A.; Rietzsch H.; Reichel A.; Bornstein S.R.; Current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus. BioMed Res Int 2013","journal-title":"BioMed Res Int"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.dsx.2015.04.007","volume":"9","author":"Noor S.","year":"2015","unstructured":"Noor S.; Zubair M.; Ahmad J.; Diabetes","journal-title":"Diabetes Metab Syndr Clin Res"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"29629","DOI":"10.3402\/dfa.v6.29629","volume":"6","author":"Pemayun T.G.","year":"2015","unstructured":"Pemayun T.G.; Naibaho R.M.; Novitasari D.; Amin N.; Minuljo T.T.; Risk factors for lower extremity amputation in patients with diabetic foot ulcers: a hospital-based case-control study. Diabet Foot Ankle 2015,6,29629","journal-title":"Diabet Foot Ankle"},{"key":"ref=15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108615","author":"Patel S.","year":"2019","unstructured":"Patel S.; Srivastava S.; Singh M.R.; Singh D.; Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomed Pharmacother 2019","journal-title":"Biomed Pharmacother"},{"key":"ref=16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01773.x","author":"Blakytny R","year":"2006","unstructured":"Blakytny R; Jude E;  The molecular biology of chronic wounds and delayed healing in diabetes 2006","journal-title":"The molecular biology of chronic wounds and delayed healing in diabetes"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s12325-014-0140-x","volume":"31","author":"Baltzis D.","year":"2014","unstructured":"Baltzis D.; Eleftheriadou I.; Veves A.; Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights. Adv Ther 2014,31(8),817-836","journal-title":"Adv Ther"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrendo.2009.276","volume":"6","author":"Calne R.Y.","year":"2010","unstructured":"Calne R.Y.; Gan S.U.; Lee K.O.; Stem cell and gene therapies for diabetes mellitus. Nat Rev Endocrinol 2010,6(3),173-177","journal-title":"Nat Rev Endocrinol"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12860-017-0137-9","volume":"18","author":"N&#xFA;&#xF1;ez-Toldr&#xE0; R.","year":"2017","unstructured":"N&#xFA;&#xF1;ez-Toldr&#xE0; R.; Mart&#xED;nez-Sarr&#xE0; E.; Gil-Recio C.; Dental pulp pluripotent-like stem cells (DPPSC), a new stem cell population with chromosomal stability and osteogenic capacity for biomaterials evaluation. BMC Cell Biol 2017,18(1),21","journal-title":"BMC Cell Biol"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.4103\/0970-0358.101286","volume":"45","author":"Sharma R.K.","year":"2012","unstructured":"Sharma R.K.; John J.R.; Role of stem cells in the management of chronic wounds. Indian J Plast Surg 2012,45(2),237-243","journal-title":"Indian J Plast Surg"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.surg.2007.10.015","volume":"143","author":"Crisostomo P.R.","year":"2008","unstructured":"Crisostomo P.R.; Markel T.A.; Wang Y.; Meldrum D.R.; Surgically relevant aspects of stem cell paracrine effects. Surgery 2008,143(5),577-581","journal-title":"Surgery"},{"key":"ref=22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088348","volume":"9","author":"Liu L.","year":"2014","unstructured":"Liu L.; Yu Y.; Hou Y.; Human umbilical cord mesenchymal stem cells transplantation promotes cutaneous wound healing of severe burned rats. PLoS One 2014,9(2)","journal-title":"PLoS One"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.scr.2013.11.005","volume":"12","author":"Kanji S.","year":"2014","unstructured":"Kanji S.; Das M.; Aggarwal R.; Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy accelerates murine cutaneous wound closure by attenuating pro-inflammatory factors and secreting IL-10. Stem Cell Res (Amst) 2014,12(1),275-288","journal-title":"Stem Cell Res (Amst)"},{"key":"ref=24","doi-asserted-by":"publisher","DOI":"10.1177\/1534734612463935","volume":"11","author":"Zou J.P.","year":"2012","unstructured":"Zou J.P.; Huang S.; Peng Y.; Mesenchymal Stem Cells\/Multipotent Potential Role in Healing. Int J Low Extrem Wounds 2012,11(4)","journal-title":"Int J Low Extrem Wounds"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1161\/CIRCRESAHA.115.305373","volume":"118","author":"Hodgkinson C.P.","year":"2016","unstructured":"Hodgkinson C.P.; Bareja A.; Gomez J.A.; Dzau V.J.; Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology. Circ Res 2016,118(1),95-107","journal-title":"Circ Res"},{"key":"ref=26","first-page":"38","volume":"57","author":"Jain P.","year":"2011","unstructured":"Jain P.; Perakath B.; Jesudason M.R.; Nayak S.; The effect of autologous bone marrow-derived cells on healing chronic lower extremity wounds: results of a randomized controlled study. Ostomy Wound Manage 2011,57(7),38-44","journal-title":"Ostomy Wound Manage"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13287-015-0001-9","volume":"6","author":"Rodriguez-Menocal L.","year":"2015","unstructured":"Rodriguez-Menocal L.; Shareef S.; Salgado M.; Shabbir A.; Van Badiavas E.; Role of whole bone marrow, whole bone marrow cultured cells, and mesenchymal stem cells in chronic wound healing. Stem Cell Res Ther 2015,6(1),24","journal-title":"Stem Cell Res Ther"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3109\/14653249.2011.553594","volume":"13","author":"Ravari H.","year":"2011","unstructured":"Ravari H.; Hamidi-Almadari D.; Salimifar M.; Bonakdaran S.; Parizadeh M.R.; Koliakos G.; Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix. Cytotherapy 2011,13(6),705-711","journal-title":"Cytotherapy"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.4049\/jimmunol.180.4.2581","volume":"180","author":"Sasaki M.","year":"2008","unstructured":"Sasaki M.; Abe R.; Fujita Y.; Ando S.; Inokuma D.; Shimizu H.; Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 2008,180(4),2581-2587","journal-title":"J Immunol"},{"journal-title":"US National Library of Medicine","key":"ref=30","unstructured":"US National Library of Medicine NIH"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13287-019-1212-2","volume":"10","author":"Nourian Dehkordi A.","year":"2019","unstructured":"Nourian Dehkordi A.; Mirahmadi Babaheydari F.; Chehelgerdi M.; Raeisi Dehkordi S.; Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther 2019,10(1),111","journal-title":"Stem Cell Res Ther"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.1182\/blood-2004-02-0586","volume":"105","author":"Jiang X.X.","year":"2005","unstructured":"Jiang X.X.; Zhang Y.; Liu B.; Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005,105(10),4120-4126","journal-title":"Blood"}],"container-title":["Current Diabetes Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/183814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.eurekaselect.com\/183814\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eurekaselect.com\/article\/download\/183814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T14:49:41Z","timestamp":1641134981000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/183814\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573399816666200716200450","relation":{},"ISSN":["1573-3998"],"issn-type":[{"type":"print","value":"1573-3998"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}