{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:05:34Z","timestamp":1785434734544,"version":"3.56.0"},"reference-count":45,"publisher":"Bentham Science Publishers Ltd.","issue":"7","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDR"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n<jats:title>Aims:<\/jats:title>\n<jats:p>We aim to investigate the efficacy and safety of pitavastatin 4 mg in a population\nof people living in the United Arab Emirates (UAE).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Pitavastatin is a member of the HMG-CoA reductase inhibitors family which was approved\nfor use in adult subjects with primary hyperlipidemia or mixed dyslipidemia. To date, no\npublished studies have assessed the efficacy and safety of pitavastatin in the United Arab Emirates.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> The main objective of the current study was to investigate the efficacy and safety of pitavastatin\nin subjects with dyslipidemia for the primary prevention of cardiovascular diseases based\non total cardiovascular risk.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> This was a multicentre (four private hospitals) prospective cohort study to analyze data\non the use of pitavastatin for dyslipidemia in adult outpatients in Abu Dhabi and Dubai, United\nArab Emirates. We have followed up the clinical profiles of subjects in four hospitals for six-weeks\nduring the period from June 2015 to June 2017. Efficacy was based on the evaluation of the mean\n(\u00b1 standard deviation) change in low-density lipoprotein cholesterol between baseline and week six\nafter the initiation of pitavastatin therapy. Safety was reported with respect to the incidence of adverse\nevents occurring with the use of pitavastatin and the development of new-onset diabetes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> A total of 400 subjects who were receiving pitavastatin 4 mg were included. The mean\nage of subjects was 50.7 \u00b110.8 years; of these, 79.0% were males. At the baseline, the mean level\nof total cholesterol was 185.4 \u00b141.5 mg\/dL, low density lipoprotein was 154.9 \u00b148.55 mg\/dL, high-\n-density lipoprotein cholesterol was 40.5 \u00b111.23 mg\/dL and fasting blood glucose was 115.0\n(\u00b116.63) mg\/dl. At the end of six weeks, low density lipoprotein levels significantly decreased to\n112.09 \u00b141.90 mg\/dl (standard mean difference (SMD) (-42.8%), 95% CI: -42.88 [-49.17 to\n-36.58] mg\/dl, P &lt;0.001), while high density lipoprotein levels improved (SMD, 95% CI: 1.77%\n[0.25 to 3.28] mg\/dl, P &lt;0.022). There were 55 subjects (13.7%) who reported various adverse\nevents such as myalgia (7.5%), sleep disorders (2.5%), and myopathy (2.2%). Furthermore, 4\n(1.0%) have had developed new-onset diabetes post-six-weeks of initiation of pitavastatin therapy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Pitavastatin 4 mg showed robust efficacy in reducing LDL-C levels and improving\nHDL-C levels in subjects with dyslipidemia. The use of pitavastatin was associated with a low discontinuation\nrate, fewer adverse events, and very limited cases of new-onset diabetes.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573399817666201228164243","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T06:25:06Z","timestamp":1609223106000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Multicenter Prospective Hospital-based Cohort Study on the Efficacy and Safety of Pitavastatin"],"prefix":"10.2174","volume":"17","author":[{"given":"Abdullah","family":"Shehab","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, United Arab Emirates University (UAEU), Al Ain,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-7810","authenticated-orcid":true,"given":"Asim Ahmed","family":"Elnour","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Program, Pharmacy College, Al Ain University, Abu Dhabi Campus,,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshaya Srikanth","family":"Bhagavathula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, United Arab Emirates University (UAEU), Al Ain,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Pulavelil","family":"Kurian","sequence":"additional","affiliation":[{"name":"Department of Cardiology; Lifeline Hospital, Abu Dhabi,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gazi","family":"Hassan","sequence":"additional","affiliation":[{"name":"Consultant Cardiologist, Gulf Medical Diagnostic Center, Abu Dhabi,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shareen","family":"AlZaabi","sequence":"additional","affiliation":[{"name":"Ambulatory Health Services (AHS), Abu Dhabi Heath Services (SEHA), Abu Dhabi,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huburt","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetology, American Hospital, UAE,United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Al-Rasadi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat,,Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","year":"2001","unstructured":"Executive summary of The third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults2001,285(19),2486-2497","journal-title":"JAMA"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","volume":"364","author":"Yusuf S.","year":"2004","unstructured":"Yusuf S.; Hawken S.; Ounpuu S.; Dans T.; Avezum A.; Lanas F.; McQueen M.; Budaj A.; Pais P.; Varigos J.; Lisheng L.; Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet INTERHEART Study Investigators2004,364(9438),937-952","journal-title":"Lancet"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","volume":"366","author":"Baigent C.","year":"2005","unstructured":"Baigent C.; Keech A.; Kearney P.M.; Blackwell L.; Buck G.; Pollicino C.; Kirby A.; Sourjina T.; Peto R.; Collins R.; Simes R.; Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet Cholesterol Treatment Trialists\u2019 (CTT) Collaborators2005,366(9493),1267-1278","journal-title":"Lancet"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","volume":"376","author":"Baigent C.","year":"2010","unstructured":"Baigent C.; Blackwell L.; Emberson J.; Holland L.E.; Reith C.; Bhala N.; Peto R.; Barnes E.H.; Keech A.; Simes J.; Collins R.; Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet Cholesterol Treatment Trialists\u2019 (CTT) Collaboration2010,376(9753),1670-1681","journal-title":"Lancet"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","volume":"63","author":"Stone N.J.","year":"2014","unstructured":"Stone N.J.; Robinson J.G.; Lichtenstein A.H.; Bairey Merz C.N.; Blum C.B.; Eckel R.H.; Goldberg A.C.; Gordon D.; Levy D.; Lloyd-Jones D.M.; McBride P.; Schwartz J.S.; Shero S.T.; Smith S.C.; Watson K.; Wilson P.W.; 2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol American College of Cardiology\/American Heart Association Task Force on Practice Guidelines2014,63(25 Pt B),2889-2934","journal-title":"J Am Coll Cardiol"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","volume":"37","author":"Catapano A.L.","year":"2016","unstructured":"Catapano A.L.; Graham I.; De Backer G.; Wiklund O.; Chapman M.J.; Drexel H.; Hoes A.W.; Jennings C.S.; Landmesser U.; Pedersen T.R.; Reiner \u017d.; Riccardi G.; Taskinen M.R.; Tokgozoglu L.; Verschuren W.M.M.; Vlachopoulos C.; Wood D.A.; Zamorano J.L.; Cooney M.T.; 2016 ESC\/EAS guidelines for the management of dyslipidemias. Eur Heart J ESC Scientific Document Group2016,37(39),2999-3058","journal-title":"Eur Heart J"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"e84350","DOI":"10.1371\/journal.pone.0084350","volume":"9","author":"Al Sifri S.N.","year":"2014","unstructured":"Al Sifri S.N.; Almahmeed W.; Azar S.; Okkeh O.; Bramlage P.; J\u00fcnger C.; Halawa I.; Ambegaonkar B.; Wajih S.; Brudi P.; Results of the Dyslipidemia International Study (DYSIS)-Middle East: clinical perspective on the prevalence and characteristics of lipid abnormalities in the setting of chronic statin treatment. PLoS One 2014,9(1),e84350","journal-title":"PLoS One"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.jacl.2015.12.021","volume":"10","author":"Al-Hashmi K.","year":"2016","unstructured":"Al-Hashmi K.; Al-Zakwani I.; Al Mahmeed W.; Arafah M.; Al-Hinai A.T.; Shehab A.; Al Tamimi O.; Al Awadhi M.; Al Herz S.; Al Anazi F.; Al Nemer K.; Metwally O.; Alkhadra A.; Fakhry M.; Elghetany H.; Medani A.R.; Yusufali A.H.; Al Jassim O.; Al Hallaq O.; Baslaib F.O.; Amin H.; Santos R.D.; Al-Waili K.; Al-Rasadi K.; Non-high-density lipoprotein cholesterol target achievement in patients on lipid-lowering drugs and stratified by triglyceride levels in the Arabian Gulf. J Clin Lipidol 2016,10(2),368-377","journal-title":"J Clin Lipidol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12944-018-0667-y","volume":"17","author":"Al-Zakwani I.","year":"2018","unstructured":"Al-Zakwani I.; Al-Mahruqi F.; Al-Rasadi K.; Shehab A.; Al Mahmeed W.; Arafah M.; Al-Hinai A.T.; Al Tamimi O.; Al Awadhi M.; Santos R.D.; Sex disparity in the management and outcomes of dyslipidemia of diabetic patients in the Arabian Gulf: findings from the CEPHEUS study. Lipids Health Dis 2018,17(1),25","journal-title":"Lipids Health Dis"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.2174\/1570161115666170705153815","volume":"16","author":"Shehab A.","year":"2018","unstructured":"Shehab A.; Al-Rasadi K.; Arafah M.; Al-Hinai A.T.; Al Mahmeed W.; Bhagavathula A.S.; Al Tamimi O.; Al Herz S.; Al Anazi F.; Al Nemer K.; Metwally O.; Alkhadra A.; Fakhry M.; Elghetany H.; Medani A.R.; Yusufali A.H.; Al Jassim O.; Al Hallaq O.; Baslaib F.O.A.S.; Alawadhi M.; Amin H.; Al-Hashmi K.; Oulhaj A.; The management of dyslipidaemia in patients with type 2 diabetes mellitus receiving lipid-lowering drugs: a sub-analysis of the CEPHEUS findings. Curr Vasc Pharmacol 2018,16(4),368-375","journal-title":"Curr Vasc Pharmacol"},{"key":"ref=11","doi-asserted-by":"publisher","unstructured":"Adams SP, Alaeiilkhchi N, Wright JM. Pitavastatin for lowering lipids Cochrane Database of systemartic reviews 2017; 7: CD012735.","DOI":"10.1002\/14651858.CD012735"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.atherosclerosissup.2017.05.001","volume":"27","author":"Pirillo A.","year":"2017","unstructured":"Pirillo A.; Catapano A.L.; Pitavastatin and HDL: Effects on plasma levels and function(s). Atheroscler Suppl 2017,27,e1-e9","journal-title":"Atheroscler Suppl"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1001\/jama.2012.366","volume":"307","author":"Boekholdt S.M.","year":"2012","unstructured":"Boekholdt S.M.; Arsenault B.J.; Mora S.; Pedersen T.R.; LaRosa J.C.; Nestel P.J.; Simes R.J.; Durrington P.; Hitman G.A.; Welch K.M.; DeMicco D.A.; Zwinderman A.H.; Clearfield M.B.; Downs J.R.; Tonkin A.M.; Colhoun H.M.; Gotto A.M.; Ridker P.M.; Kastelein J.J.; Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 2012,307(12),1302-1309","journal-title":"JAMA"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"654","DOI":"10.5551\/jat.1719","volume":"16","author":"Teramoto T.","year":"2009","unstructured":"Teramoto T.; Shimano H.; Yokote K.; Urashima M.; Effects of pitavastatin (LIVALO Tablet) on high density lipoprotein cholesterol (HDL-C) in hypercholesterolemia. J Atheroscler Thromb 2009,16(5),654-661","journal-title":"J Atheroscler Thromb"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.atherosclerosis.2009.12.009","volume":"210","author":"Ose L.","year":"2010","unstructured":"Ose L.; Budinski D.; Hounslow N.; Arneson V.; Long-term treatment with pitavastatin is effective and well tolerated by patients with primary hypercholesterolemia or combined dyslipidemia. Atherosclerosis 2010,210(1),202-208","journal-title":"Atherosclerosis"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1517\/14656561003641990","volume":"11","author":"Teramoto T.","year":"2010","unstructured":"Teramoto T.; Shimano H.; Yokote K.; Urashima M.; New evidence on pitavastatin: efficacy and safety in clinical studies. Expert Opin Pharmacother 2010,11(5),817-828","journal-title":"Expert Opin Pharmacother"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s40256-017-0213-8","volume":"17","author":"Hoy S.M.","year":"2017","unstructured":"Hoy S.M.; Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs 2017,17(2),157-168","journal-title":"Am J Cardiovasc Drugs"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/S1567-5688(09)70926-2","volume":"10","author":"Stender S.","year":"2009","unstructured":"Stender S.; Hounslow N.; Robust efficacy of pitavastatin and comparable safety to pravastatin. Atheroscler Suppl 2009,10,770","journal-title":"Atheroscler Suppl"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1161\/01.cir.0000437738.63853.7a","volume":"129","author":"Stone N.J.","year":"2014","unstructured":"Stone N.J.; Robinson J.G.; Lichtenstein A.H.; Bairey Merz C.N.; Blum C.B.; Eckel R.H.; Goldberg A.C.; Gordon D.; Levy D.; Lloyd-Jones D.M.; McBride P.; Schwartz J.S.; Shero S.T.; Smith S.C.; Watson K.; Wilson P.W.; Eddleman K.M.; Jarrett N.M.; LaBresh K.; Nevo L.; Wnek J.; Anderson J.L.; Halperin J.L.; Albert N.M.; Bozkurt B.; Brindis R.G.; Curtis L.H.; DeMets D.; Hochman J.S.; Kovacs R.J.; Ohman E.M.; Pressler S.J.; Sellke F.W.; Shen W.K.; Smith S.C.; Tomaselli G.F.; 2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation American College of Cardiology\/American Heart Association Task Force on Practice Guidelines2014,129(25)(Suppl. 2),S1-S45","journal-title":"Circulation"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1093\/eurheartj\/ehr158","volume":"32","author":"Reiner Z.","year":"2011","unstructured":"Reiner Z.; Catapano A.L.; De Backer G.; Graham I.; Taskinen M.R.; Wiklund O.; Agewall S.; Alegria E.; Chapman M.J.; Durrington P.; Erdine S.; Halcox J.; Hobbs R.; Kjekshus J.; Filardi P.P.; Riccardi G.; Storey R.F.; Wood D.; ESC\/EAS guidelines for the management of dyslipidemias: the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J European Association for Cardiovascular Prevention","journal-title":"Eur Heart J"},{"key":"ref=21","year":"2017","unstructured":"Centre for drug evaluation and research US Food and Drug Administration 2017 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2009\/022363s000_MedR_P1.pdf","journal-title":"US Food and Drug Administration"},{"key":"ref=22","first-page":"251","volume":"52","author":"Saito Y.","year":"2002","unstructured":"Saito Y.; Yamada N.; Teramoto T.; Itakura H.; Hata Y.; Nakaya N.; Mabuchi H.; Tushima M.; Sasaki J.; Goto Y.; Ogawa N.; Clinical efficacy of pitavastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in patients with hyperlipidemia. Dose-finding study using the double-blind, three-group parallel comparison. Arzneimittelforschung 2002,52(4),251-255","journal-title":"Arzneimittelforschung"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1056\/NEJMoa1409065","volume":"371","author":"Rohatgi A.","year":"2014","unstructured":"Rohatgi A.; Khera A.; Berry J.D.; Givens E.G.; Ayers C.R.; Wedin K.E.; Neeland I.J.; Yuhanna I.S.; Rader D.R.; de Lemos J.A.; Shaul P.W.; HDL cholesterol efflux capacity and incident cardiovascular events. N Engl J Med 2014,371(25),2383-2393","journal-title":"N Engl J Med"},{"key":"ref=24","first-page":"205","volume":"10","author":"Subedi B.H.","year":"2014","unstructured":"Subedi B.H.; Joshi P.H.; Jones S.R.; Martin S.S.; Blaha M.J.; Michos E.D.; Current guidelines for high-density lipoprotein cholesterol in therapy and future directions. Vasc Health Risk Manag 2014,10,205-216","journal-title":"Vasc Health Risk Manag"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.jacl.2018.01.002","volume":"12","author":"Otvos J.D.","year":"2018","unstructured":"Otvos J.D.; Guyton J.R.; Connelly M.A.; Akapame S.; Bittner V.; Kopecky S.L.; Lacy M.; Marcovina S.M.; Muhlestein J.B.; Boden W.E.; Relations of GlycA and lipoprotein particle subspecies with cardiovascular events and mortality: A post hoc analysis of the AIM-HIGH trial. J Clin Lipidol 2018,12(2),348-355.e2","journal-title":"J Clin Lipidol"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1253\/circj.CJ-10-1163","volume":"75","author":"Maruyama T.","year":"2011","unstructured":"Maruyama T.; Takada M.; Nishibori Y.; Fujita K.; Miki K.; Masuda S.; Horimatsu T.; Hasuike T.; Comparison of preventive effect on cardiovascular events with different statins. -The CIRCLE study-. Circ J 2011,75(8),1951-1959","journal-title":"Circ J"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.atherosclerosis.2008.02.008","volume":"201","author":"Yokote K.","year":"2008","unstructured":"Yokote K.; Bujo H.; Hanaoka H.; Shinomiya M.; Mikami K.; Miyashita Y.; Nishikawa T.; Kodama T.; Tada N.; Saito Y.; Multicenter collaborative randomized parallel group comparative study of pitavastatin and atorvastatin in Japanese hypercholesterolemic patients: collaborative study on hypercholesterolemia drug intervention and their benefits for atherosclerosis prevention (CHIBA study). Atherosclerosis 2008,201(2),345-352","journal-title":"Atherosclerosis"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1365-2710.2011.01274.x","volume":"37","author":"Poolsup N.","year":"2012","unstructured":"Poolsup N.; Suksomboon N.; Wongyaowarat K.; Rungkanchananon B.; Niyomrat P.; Kongsuwan S.; Meta-analysis of the comparative efficacy and safety of pitavastatin and atorvastatin in patients with dyslipidaemia. J Clin Pharm Ther 2012,37(2),166-172","journal-title":"J Clin Pharm Ther"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.atherosclerosis.2015.10.005","volume":"243","author":"Verdoia M.","year":"2015","unstructured":"Verdoia M.; Nardin M.; Sartori C.; Pergolini P.; Rolla R.; Barbieri L.; Marino P.; Bellomo G.; Suryapranata H.; De Luca G.; Impact of atorvastatin or rosuvastatin co-administration on platelet reactivity in patients treated with dual antiplatelet therapy. Atherosclerosis Novara Atherosclerosis Study Group (NAS)2015,243(2),389-394","journal-title":"Atherosclerosis"},{"key":"ref=30","first-page":"7","author":"Ovrakh T.","year":"2017","unstructured":"Ovrakh T.; Serik S.; Kochubiei O.; Impact of atorvastatin and rosuvastatin on residual on-clopidogrel treatment platelet reactivity in patients with ischemic heart disease and type 2 diabetes mellitus after acute coronary syndrome. Georgian Med News 2017(265),7-14","journal-title":"Georgian Med News"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1002\/clc.22709","volume":"40","author":"Godino C.","year":"2017","unstructured":"Godino C.; Pavon A.G.; Mangieri A.; Salerno A.; Cera M.; Monello A.; Chieffo A.; Magni V.; Cappelletti A.; Margonato A.; Colombo A.; Platelet reactivity in response to loading dose of atorvastatin or rosuvastatin in patients with stable coronary disease before percutaneous coronary intervention: The STATIPLAT randomized study. Clin Cardiol 2017,40(8),605-611","journal-title":"Clin Cardiol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1517\/14656566.2012.660525","volume":"13","author":"Teramoto T.","year":"2012","unstructured":"Teramoto T.; The clinical impact of pitavastatin: comparative studies with other statins on LDL-C and HDL-C. Expert Opin Pharmacother 2012,13(6),859-865","journal-title":"Expert Opin Pharmacother"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"e001974","DOI":"10.1161\/JAHA.112.001974","volume":"1","author":"Nagasawa S.Y.","year":"2012","unstructured":"Nagasawa S.Y.; Okamura T.; Iso H.; Tamakoshi A.; Yamada M.; Watanabe M.; Murakami Y.; Miura K.; Ueshima H.; Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group: a pooled analysis of 65 594 individuals from 10 cohort studies in Japan. J Am Heart Assoc Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group2012,1(5),e001974","journal-title":"J Am Heart Assoc"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2016.03.016","volume":"248","author":"Peters S.A.","year":"2016","unstructured":"Peters S.A.; Singhateh Y.; Mackay D.; Huxley R.R.; Woodward M.; Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis. Atherosclerosis 2016,248,123-131","journal-title":"Atherosclerosis"},{"key":"ref=35","doi-asserted-by":"publisher","unstructured":"Jeong SM, Choi S, Kim K, et al. Effect of change in Total cholesterol levels on cardiovascular disease among young adults. J Am Heart Assoc 2018; 7(12)","DOI":"10.1161\/JAHA.118.008819"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1161\/CIRCULATIONAHA.117.032615","volume":"137","author":"Taguchi I.","year":"2018","unstructured":"Taguchi I.; Iimuro S.; Iwata H.; Takashima H.; Abe M.; Amiya E.; Ogawa T.; Ozaki Y.; Sakuma I.; Nakagawa Y.; Hibi K.; Hiro T.; Fukumoto Y.; Hokimoto S.; Miyauchi K.; Yamazaki T.; Ito H.; Otsuji Y.; Kimura K.; Takahashi J.; Hirayama A.; Yokoi H.; Kitagawa K.; Urabe T.; Okada Y.; Terayama Y.; Toyoda K.; Nagao T.; Matsumoto M.; Ohashi Y.; Kaneko T.; Fujita R.; Ohtsu H.; Ogawa H.; Daida H.; Shimokawa H.; Saito Y.; Kimura T.; Inoue T.; Matsuzaki M.; Nagai R.; Highdose versus low-dose pitavastatin in Japanese patients with stable coronary artery disease (REAL-CAD): a randomized superiority trial. Circulation 2018,137(19),1997-2009","journal-title":"Circulation"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11883-009-0039-1","volume":"11","author":"Ridker P.M.","year":"2009","unstructured":"Ridker P.M.; Moving toward new statin guidelines in a post-JUPITER world: principles to consider. Curr Atheroscler Rep 2009,11(4),249-256","journal-title":"Curr Atheroscler Rep"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1001\/jama.2011.860","volume":"305","author":"Preiss D.","year":"2011","unstructured":"Preiss D.; Seshasai S.R.; Welsh P.; Murphy S.A.; Ho J.E.; Waters D.D.; DeMicco D.A.; Barter P.; Cannon C.P.; Sabatine M.S.; Braunwald E.; Kastelein J.J.; de Lemos J.A.; Blazing M.A.; Pedersen T.R.; Tikkanen M.J.; Sattar N.; Ray K.K.; Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA 2011,305(24),2556-2564","journal-title":"JAMA"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0140-6736(09)61965-6","volume":"375","author":"Sattar N.","year":"2010","unstructured":"Sattar N.; Preiss D.; Murray H.M.; Welsh P.; Buckley B.M.; de Craen A.J.; Seshasai S.R.; McMurray J.J.; Freeman D.J.; Jukema J.W.; Macfarlane P.W.; Packard C.J.; Stott D.J.; Westendorp R.G.; Shepherd J.; Davis B.R.; Pressel S.L.; Marchioli R.; Marfisi R.M.; Maggioni A.P.; Tavazzi L.; Tognoni G.; Kjekshus J.; Pedersen T.R.; Cook T.J.; Gotto A.M.; Clearfield M.B.; Downs J.R.; Nakamura H.; Ohashi Y.; Mizuno K.; Ray K.K.; Ford I.; Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010,375(9716),735-742","journal-title":"Lancet"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"e000438","DOI":"10.1136\/bmjdrc-2017-000438","volume":"5","author":"Crandall J.P.","year":"2017","unstructured":"Crandall J.P.; Mather K.; Rajpathak S.N.; Goldberg R.B.; Watson K.; Foo S.; Ratner R.; Barrett-Connor E.; Temprosa M.; Statin use and risk of developing diabetes: results from the Diabetes Prevention Program. BMJ Open Diabetes Res Care 2017,5(1),e000438","journal-title":"BMJ Open Diabetes Res Care"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s12325-011-0057-6","volume":"28","author":"Eriksson M.","year":"2011","unstructured":"Eriksson M.; Budinski D.; Hounslow N.; Long-term efficacy of pitavastatin versus simvastatin. Adv Ther 2011,28(9),799-810","journal-title":"Adv Ther"},{"key":"ref=42","first-page":"733","volume":"10","author":"Chamberlin K.W.","year":"2015","unstructured":"Chamberlin K.W.; Baker W.L.; Benefit-risk assessment of pitavastatin for the treatment of hypercholesterolemia in older patients. Clin Interv Aging 2015,10,733-740","journal-title":"Clin Interv Aging"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1111\/j.1463-1326.2011.01477.x","volume":"13","author":"Gumprecht J.","year":"2011","unstructured":"Gumprecht J.; Gosho M.; Budinski D.; Hounslow N.; Comparative long-term efficacy and tolerability of pitavastatin 4 mg and atorvastatin 20-40 mg in patients with type 2 diabetes mellitus and combined (mixed) dyslipidaemia. Diabetes Obes Metab 2011,13(11),1047-1055","journal-title":"Diabetes Obes Metab"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s40261-014-0215-0","volume":"34","author":"Jiang Z.","year":"2014","unstructured":"Jiang Z.; Gong R.R.; Qiu L.; Wang Q.; Su M.; Liu X.J.; Hu M.S.; Lin J.; Fang D.Z.; Efficacy and safety of pitavastatin versus simvastatin: a meta-analysis of randomized controlled trials. Clin Drug Investig 2014,34(9),599-608","journal-title":"Clin Drug Investig"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2174\/1570161117666190408164908","volume":"18","author":"Shehab A.","year":"2020","unstructured":"Shehab A.; Bhagavathula A.S.; Elnour A.A.; Al-Rasadi K.; Al-Shamsi S.; The incidence of adverse drug reactions in patients treated with statins in the emirates: A retrospective cohort study. Curr Vasc Pharmacol 2020,18(2),193-199","journal-title":"Curr Vasc Pharmacol"}],"container-title":["Current Diabetes Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1573399817666201228164243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189541\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1573399817666201228164243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T16:50:26Z","timestamp":1660668626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189541\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573399817666201228164243","relation":{},"ISSN":["1573-3998"],"issn-type":[{"value":"1573-3998","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e122820189541"}}