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This disorder, which is also called the mother of all diseases, possesses high\npathogenicity and results in the emergence of many disorders. One of the known correlated diseases\nis pancreatic cancer which can be accompanied by diabetes mellitus. Therefore, finding the association\nbetween these diseases and common genes is urgent.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>In this study, in order to survey the relationship between diabetes mellitus and pancreatic\ncancer, the common genes of these disorders were analyzed by bioinformatics tools.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>For this purpose, we screened 17 shared genes from microarray data downloaded from\nthe Gene Expression Omnibus (GEO) database. In addition, the relationship between identified\ngenes was constructed by STRING and DAVID tools.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>In total, 112 genes were identified to be differentially expressed. Among these, 17 genes\nwere found to be common, including two genes that were down-regulated and others that were upregulated.\nOther analyses showed that most of the genes were enriched in Vibrio cholera infection\nand the mTOR signaling pathway. The biological processes of such genes included oxygen and gas\ntransport, phagosome acidification, and GTPase activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this study, 17 common genes that had not previously been considered in diabetes\nand pancreatic cancer were screened, which can be further considered for clinical approaches and\nin vitro studies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573399818666220118095952","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T04:07:50Z","timestamp":1642565270000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Association Between Diabetes Mellitus and Pancreatic Cancer"],"prefix":"10.2174","volume":"19","author":[{"given":"Salar","family":"Bakhtiyari","sequence":"first","affiliation":[{"name":"Department\nof Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monireh","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinat","family":"Shams","sequence":"additional","affiliation":[{"name":"Department\nof Biological Science, Kharazmi University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh Sadat","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, School of Allied\nMedicine, Iran University of Medical Science, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katayoun Dadeh","family":"Amirfard","sequence":"additional","affiliation":[{"name":"Department of Microbiology, North Tehran Branch, Islamic\nAzad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohadeseh Soleymani","family":"Sadrabadi","sequence":"additional","affiliation":[{"name":"Department of Biology, Shahid Bahonar University of Kerman, Faculty of Science,\nKerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Gheysarzadeh","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran"},{"name":"Department\nof Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karimeh","family":"Haghani","sequence":"additional","affiliation":[{"name":"Department\nof Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/1753-0407.12644","volume":"10","author":"Carracher A.M.","year":"2018","unstructured":"Carracher A.M.; Marathe P.H.; Close K.L.; International diabetes federation 2017. 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