{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:02:51Z","timestamp":1794254571924,"version":"4.9.0"},"reference-count":30,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CHYR"],"published-print":{"date-parts":[[2020,2,13]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Depression and hypertension are medical problems both with clearly restricted\npharmacotherapies, along with a high prevalence around the world. In fact, an intensive\ndiscussion in the field is that a dysregulation of the intracellular Ca2+ homeostasis (e.g. excess of\nintracellular Ca2+) contributes to the pathogenesis of both hypertension and depression. Furthermore,\ndepression rises the risk of hypertension incidence. Indeed, several data support the concept\nthat depression is an independent risk issue for hypertension.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Then, which are the possible cellular mechanisms involved in this link between depression\nand hypertension? Considering our previous reports about the Ca2+ and cAMP signalling\npathways (Ca2+\/cAMP signalling), in this review I have discussed the virtual involvement of the\nCa2+\/cAMP signalling in this link (between depression and hypertension). Then, it is important to\nconsider depression into account during the process of prevention, and treatment, of hypertension.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573402115666190116095223","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T11:22:41Z","timestamp":1547637761000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Depression Rises the Risk of Hypertension Incidence: Discussing the Link through the Ca2+\/cAMP Signalling"],"prefix":"10.2174","volume":"16","author":[{"given":"Leandro B.","family":"Bergantin","sequence":"first","affiliation":[{"name":"Department of Pharmacology-Escola Paulista de Medicina-Universidade Federal de Sao Paulo, Rua Pedro de Toledo, 669-Vila Clementino, Sao Paulo-SP, Postal Code: 04039-032, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/HJH.0b013e32835080b7","volume":"30","author":"Meng L.","year":"2012","unstructured":"Meng L.; Chen D.; Yang Y.; Zheng Y.; Hui R.; Depression increases the risk of hypertension incidence: A meta-analysis of prospective cohort studies. 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