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SARS-CoV-2 may also predispose infected individuals with existing HTN to a greater risk of severe COVID-19 complications. In the duality of COVID-19 and HTN, the imbalance of ACE and ACE2 results in an elevation of AngII and a decrease in Ang (1-7), a hyperinflammatory response and endothelial dysfunction. Endothelial dysfunction is the main factor that predisposes hypertensive patients to severe COVID-19 and vice-versa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Conclusion: Despite the increase in ACE2 expression in hypertensive SARS-CoV-2 infected pa-tients, ARBs\/ACE inhibitors do not influence their severity and clinical outcomes, implicating continued usage. Future large scale clinical trials are warranted to further elucidate the association between HTN and SARS-CoV-2 infection; as well as the use of ARBs\/ACEIs in SARS-CoV-2 hy-pertensive patients.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1573402118666220816090809","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T11:09:55Z","timestamp":1660734595000},"page":"130-137","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unravelling the Mechanistic Role of ACE2 and TMPRSS2 in Hypertension: A Risk Factor for COVID-19"],"prefix":"10.2174","volume":"18","author":[{"given":"Nalini","family":"Govender","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Health Sciences, Durban University of Technology, Durban 4001, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olive","family":"Khaliq","sequence":"additional","affiliation":[{"name":"The Department of Paediatrics and Child Health, Faculty of Health Sciences, The University of the Free State, Bloemfontein 9300, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagidesa","family":"Moodley","sequence":"additional","affiliation":[{"name":"Women\u2019s Health and HIV Research Group, Department of Obstetrics and Gynaecology, School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thajasvarie","family":"Naicker","sequence":"additional","affiliation":[{"name":"Optics &amp; Imaging Centre, Doris Duke Medical Research Institute, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"year":"2022","unstructured":"Coronavirus (COVID-19) Dashboard: World Health Organization WHOAvailable from: 2022","journal-title":"Coronavirus (COVID-19) Dashboard: World Health Organization","key":"ref=1"},{"year":"2022","unstructured":"WHO Africa \/ Health topics \/ Coronavirus (COVID-19) World Health Organization Available from: 2022","key":"ref=2"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"5077","DOI":"10.1016\/j.cell.2021.09.010","volume":"184","author":"Cevik M.","year":"2021","unstructured":"Cevik M.; Grubaugh N.D.; Iwasaki A.; Openshaw P.; COVID-19 vaccines: Keeping pace with SARS-CoV-2 variants. 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