{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:33:40Z","timestamp":1783474420897,"version":"3.55.0"},"reference-count":27,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCR"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Systemic Mastocytosis (SM) is a disorder of excessive mast cell infiltration\nin multiple organ tissues. Atherosclerosis is a major risk factor for developing acute coronary\nsyndrome. In addition to lipid accumulation in the arterial wall, inflammation plays an important\nrole in the pathogenesis of plaque rupture and activating the thrombosis cascade. The Mast cells\ncontribution to plaque destabilization has been well established in multiple animal and human studies.\nIn a recent study, SM has been proven to be associated with a higher incidence of acute coronary\nsyndrome even with lower plasma lipids levels. The study showed that 20% of patients with\nSM had cardiovascular events compared to only 6% in the control group with adjustment to all cardiac\nrisk factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case:<\/jats:title>\n<jats:p>We presented a patient with no risk factors for heart disease other than old age and history of\nSM who developed acute myocardial infarction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>SM can be life-threatening and can result in ACS, anaphylactic reaction, syncope, or\ncardiac arrest. Clinicians should have a high index of suspicion of acute coronary syndrome (ACS)\noccurrence in the setting of inflammatory conditions, such as SM and KS, and vice versa, where\nSM should be considered or ruled out in patients who suffer from anaphylaxis and cardiac arrest or\nmyocardial infarction.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573403x16666200331123242","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T19:29:48Z","timestamp":1585682988000},"page":"333-337","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute Myocardial Infarction in Systemic Mastocytosis: Case Report With Literature Review on the Role of Inflammatory Process in Acute Coronary Syndrome"],"prefix":"10.2174","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-5764","authenticated-orcid":true,"given":"Ayman","family":"Battisha","sequence":"first","affiliation":[{"name":"University of Massachusetts Medical School\u2014Baystate, Springfield, MA 01107, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2643-0434","authenticated-orcid":true,"given":"Khalid","family":"Sawalha","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School\u2014Baystate, Springfield, MA 01107, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-380X","authenticated-orcid":true,"given":"Bader","family":"Madoukh","sequence":"additional","affiliation":[{"name":"Overland Park Regional Medical Center-HCA Midwest Health, Kansas, KS 66215, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-3152","authenticated-orcid":true,"given":"Omar","family":"Sheikh","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio, San Antonio, TX78229, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7175-3881","authenticated-orcid":true,"given":"Karim","family":"Doughem","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, Houston, TX 77030, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Al-Akchar","sequence":"additional","affiliation":[{"name":"Southern Illinois University School of Medicine, Springfield, IL 62701, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-7887","authenticated-orcid":true,"given":"Mohammed","family":"Al-Sadawi","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2527-9031","authenticated-orcid":true,"given":"Shakil","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"15S","DOI":"10.1016\/S0735-1097(02)02834-6 PMID: 12644336","volume":"41","author":"Shah P.K.","year":"2003","unstructured":"Shah P.K.; Mechanisms of plaque vulnerability and rupture. 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