{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:49:26Z","timestamp":1784054966556,"version":"3.55.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["6-15-10001"],"award-info":[{"award-number":["6-15-10001"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCR"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>There is considerable evidence that autophagy in cardiomyocytes is activated by hypoxia\/\nreoxygenation (H\/R) or in hearts by ischemia\/reperfusion (I\/R). Depending upon the experimental\nmodel and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective)\nor deleterious (exacerbate I\/R injury). Besides the conundrum as to whether or not autophagy\nis an adaptive process, it is clearly regulated by a number of diverse molecules, including\nreactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The\npurpose of this review was to address briefly the controversy regarding the role of autophagy in\nthis setting and to examine a variety of disparate molecules that are involved in its regulation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573403x16666201014142446","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T06:27:29Z","timestamp":1602743249000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-3844","authenticated-orcid":true,"given":"Andrey","family":"Krylatov","sequence":"first","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of 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Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, CA 90048, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Cardiology 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