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diffuse patchy osteolytic\nlesions or punctate destruction. However, it is difficult to accurately determine the fine structure of bone affected by MM\nwith these techniques due to low specificity and sensitivity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>This study aimed to investigate the microscopic anatomical morphology and analyze the microstructure\nchanges of trabeculae affected by multiple myeloma (MM) based on micro-CT.\nMethods: MM-affected and normal trabecular bone samples were imaged by micro-CT to obtain bone structure\nparameters to assess statistical differences between them and evaluate the degree of microstructural damage of MMaffected trabeculae.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>MM-affected and normal trabecular bone samples were imaged by micro-CT to obtain\nbone structure parameters to assess statistical differences between them and evaluate the degree of\nmicrostructural damage of MM-affected trabeculae.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Micro CT images clearly showed the microstructure of MM-affected trabeculae. The degree\nof trabecular osteoporosis varied with the severity of MM. There were significant differences\nin the structural parameters between MM-affected and normal trabeculae (P &lt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p> Micro-CT clearly reveals the microstructure of MM-affected trabeculae. The obtained bone structure data\nwill help to determine the degree of bone damage caused by MM and assess the efficacy. <\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573405616666201015144015","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T06:28:07Z","timestamp":1602829687000},"page":"513-516","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Evaluation of the Multiple Myeloma Pathological Osseous Tissue of Microarchitecture"],"prefix":"10.2174","volume":"17","author":[{"given":"Lianxiang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Human Anatomy Teaching and Research Section (Digital Medical Center), Inner Mongolia Medical University Basic Medical College, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Human Anatomy Teaching and Research Section (Digital Medical Center), Inner Mongolia Medical University Basic Medical College, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Inner Mongolia People's Hospital, Hohhot, 010017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoke","family":"Su","sequence":"additional","affiliation":[{"name":"Graduate School, Inner Mongolia Medical University, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebin","family":"Xu","sequence":"additional","affiliation":[{"name":"Graduate School, Inner Mongolia Medical University, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongchen","family":"Lv","sequence":"additional","affiliation":[{"name":"Graduate School, Inner Mongolia Medical University, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Liu","sequence":"additional","affiliation":[{"name":"Graduate School, Inner Mongolia Medical University, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohe","family":"Li","sequence":"additional","affiliation":[{"name":"Human Anatomy Teaching and Research Section (Digital Medical Center), Inner Mongolia Medical University Basic Medical College, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Li","sequence":"additional","affiliation":[{"name":"Human Anatomy Teaching and Research Section (Digital Medical Center), Inner Mongolia Medical University Basic Medical College, Hohhot, 010059, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.clml.2016.03.006","volume":"16","author":"Sergentanis TN.","year":"2016","unstructured":"Sergentanis TN.; Kastritis E.; Terpos E.; Dimopoulos MA.; Psaltopoulou T; Cytogeneticsand survival of multiple myeloma: isolated and combined effects. 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