{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:39:53Z","timestamp":1778287193335,"version":"3.51.4"},"reference-count":26,"publisher":"Bentham Science Publishers Ltd.","issue":"7","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMIR"],"published-print":{"date-parts":[[2021,8,5]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Callosal Angle (CA) and Evans Index (EI) are considered as imaging biomarkers\nto diagnose normal-pressure hydrocephalus using traditional MR measurement methods.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> The current study was aimed to evaluate the differential diagnostic value of CA and EI in the mild cognitive\nimpairment (MCI) and Alzheimer\u2019s disease (AD).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Five-hundred and two subjects were selected from the Alzheimer's Disease Neuroimaging\nInitiative (ADNI) database, which included 168 Normal Controls (NC), 233 MCI and 101 AD\npatients. The structural MR images were interactively applied with multiplanar reconstruction to\nmeasure the CA and EI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>CA presented no significant difference among NC, MCI and AD groups (H value = 3.848,\nP value = 0.146), and EI demonstrated higher value in MCI and AD groups than that in NC groups\n(P = 0.000 and 0.001, respectively). MCI group had significant larger EI (0.29\u00b10.04) than\n(0.27\u00b10.03) NC group in 70-75 years old sub-groups. ROC showed that the area under the curve\nwas 0.704\u00b10.045 for NC-MCI in 70-75 years old groups. The correlation analysis indicated that EI\nwas significantly negatively related to MMSE scores of MCI patients (r = -0.131, P = 0.046).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> EI might serve as a screening imaging biomarker for MCI in 70-75 years old, and show limited differential\nvalue for the diagnosis of AD. CA could present no diagnostic value for MCI and AD in the current study.\n<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573405616666201223150004","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T10:14:21Z","timestamp":1610014461000},"page":"889-896","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Differential Diagnostic Value of the Callosal Angle and Evans Index in Mild Cognitive Impairment and Alzheimer's Disease"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-8691","authenticated-orcid":true,"given":"Mengqi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-2278","authenticated-orcid":true,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linxiong","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-8593","authenticated-orcid":true,"given":"Wenping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-6040","authenticated-orcid":true,"given":"Botao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-8013","authenticated-orcid":true,"given":"Zhiye","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3171\/2013.8.JNS13575","volume":"120","author":"Virhammar J.","year":"2014","unstructured":"Virhammar J.; Laurell K.; Cesarini K.G.; Larsson E.M.; The callosal angle measured on MRI as a predictor of outcome in idiopathic normal-pressure hydrocephalus. 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