{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:13:08Z","timestamp":1768720388570,"version":"3.49.0"},"reference-count":28,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2020,4,17]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Nucleoside analogues are well-known antitumor, antiviral, and chemotherapeutic\nagents. Alterations on both their sugar and the heterocyclic parts may lead to significant\nchanges in the spectrum of their biological activity and the degree of selective toxicity, as\nwell as in their physicochemical properties.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>C5-arylalkynyl-\u03b2-D-ribofuranonucleosides 3-6, 3\u0384-deoxy 12-15, 3\u0384-deoxy-3\u0384-C-methyl-\n\u03b2-D-ribofurananucleosides 18-21 and 2\u0384-deoxy-\u03b2-D-ribofuranonucleosides 23-26 of uracil, were\nsynthesized using a one-step Sonogashira reaction under microwave irradiation and subsequent\ndeprotection.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>All newly synthesized nucleosides were tested for their antitumor or antiviral activity.\nModerate cytostatic activity against cervix carcinoma (HeLa), murine leukemia (L1210) and human\nlymphocyte (CEM) tumor cell lines was displayed by the protected 3\u0384-deoxy derivatives\n12b,12c,12d, and the 3\u0384-deoxy-3\u0384-methyl 18a,18b,18c. The antiviral evaluation revealed appreciable\nactivity against Coxsackie virus B4, Respiratory syncytial virus, Yellow Fever Virus and Human\nCoronavirus (229E) for the 3\u0384-deoxy compounds 12b,14, and the 3\u0384-deoxy-3\u0384-methyl\n18a,18c,18d, accompanied by low cytotoxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>This report describes the total and facile synthesis of modified furanononucleosides\nof uracil, with alterations on both the sugar and the heterocyclic portions. Compounds 12b,14 and\n18a,c,d showed noticeable antiviral activity against a series of RNA viruses and merit further biological\nand structural optimization investigations.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406415666190225112950","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T11:33:01Z","timestamp":1551094381000},"page":"368-384","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or\/and Antiviral Agents"],"prefix":"10.2174","volume":"16","author":[{"given":"Nikolaos","family":"Kollatos","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Mitsos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Manta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Tzioumaki","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Giannakas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Alexouli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aggeliki","family":"Panagiotopoulou","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Applications, National Centre for Scientific Research \u201cDemokritos\u201d, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Andrei","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Komiotis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Laboratory of Bioorganic Chemistry, University of Thessaly, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1021\/jm040027j","volume":"47","author":"Zhou W.","year":"2004","unstructured":"Zhou W.; Gumina G.; Chong Y.; Wang J.; Shinazi R.F.; Chu C.K.; Synthesis, structure-activity relationships, and drug resistance of \u03b2-D-3\u00b4-fluoro-2\u00b4,3\u00b4-unsaturated nucleosides as anti-HIV agents. 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