{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:04:46Z","timestamp":1788793486620,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento Pessoal de N\u00edvel Superior - Brasil","doi-asserted-by":"publisher","award":["Finance code 001"],"award-info":[{"award-number":["Finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP - 2016\/10847-9"],"award-info":[{"award-number":["FAPESP - 2016\/10847-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2020,1,16]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>More than 10 million people around the world are afflicted by Neglected Tropical Diseases,\nsuch as Chagas Disease, Human African Trypanosomiasis, and Leishmania. These diseases\nmostly occur in undeveloped countries that suffer from a lack of economic incentive, research, and\npolicy for new compound development. Sulfonamide moieties are effective scaffolds present in\nseveral compounds that are determinants to treat various diseases, principally neglected tropical\ndiseases. This review article examines the contribution of these scaffolds in medicinal chemistry in\nthe last five years, focusing on three trypanosomatid parasites: Trypanosoma cruzi, Trypanosoma\nbrucei, and Leishmania ssp. We also present perspectives for their use in drug designs in an effort\nto contribute to new drug development. In addition, we consider the physicochemical parameters,\nwhose molecules all presented according to Lipinski's rule. The correlation between the selective\nindex and LogP was evaluated, showing that sulfonamide derivatives can act differently against\neach trypanosomatid parasite. Moreover, the approaches of novel drugs and technologies are very\nimportant for the eventual drug discovery against trypanosomatid diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406415666190620141109","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T08:18:45Z","timestamp":1561018725000},"page":"24-38","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites including <i>Trypanosoma cruzi, Trypanosoma brucei<\/i>, and <i>Leishmania ssp<\/i>"],"prefix":"10.2174","volume":"16","author":[{"given":"Cau\u00ea B.","family":"Scarim","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael C.","family":"Chelucci","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean L.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung M.","family":"Chin","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/172878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T09:52:30Z","timestamp":1579168350000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/172878\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,16]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573406415666190620141109","relation":{},"ISSN":["1573-4064"],"issn-type":[{"value":"1573-4064","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1,16]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}