{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T05:39:55Z","timestamp":1794634795612,"version":"4.9.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"5","funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["172011"],"award-info":[{"award-number":["172011"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2021,5,24]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>In order to make some progress in discovering the more effective way to\neliminate ROS which cause the oxidative stress in organism in humans and bearing in mind the\nfact that ethyl-2-hydroxy-4-aryl(alkyl)-4-oxo-2-butenoates (\u03b2-diketonates) belong to a class of biologically\nactive compounds, series of \u03b2-diketonates were synthesized, characterized, and tested to\nevaluate there antioxidant activity. Further, to investigate how coordination to copper(II) ion affects\nthe activity of \u03b2-diketonates, appropriate complexes were synthesized and characterized.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>All complexes were characterized by UV-Vis, IR, and EPR spectroscopy, MS spectrometry,\nand elemental analysis. Fluorescence spectroscopic method was used for investigations of the\ninteractions between biomacromolecules (DNA or BSA) and compound 2E. Viscosity measurements\nand molecular docking study were performed to confirm the mode of interactions between\nDNA and BSA and compound 2E.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Scavenging activity on DPPH radical revealed that compounds 2A, 2B, and 2E possess\nlargest free radical scavenging, comparable to standard while results of superoxide anion scavenging\nactivities of tested samples showed that maximum scavenging activity (IC<jats:sub>50<\/jats:sub>=168.92 \u03bcg\/mL)\nwas found for 2E, very similar to standard ascorbic acid, followed by 2B and 2G. Results of the\ninteractions between biomacromolecules and 2E indicated that 2E has the affinity to displace EB\nfrom the EB-DNA complex through intercalation [K<jats:sub>sv<\/jats:sub> = (3.7 \u00b1 0.1) \u00d7 10<jats:sup>3<\/jats:sup> M<jats:sup>-1<\/jats:sup>], while K<jats:sub>a<\/jats:sub> value obtained\nvia titration of BSA with 2E [K<jats:sub>a<\/jats:sub> = (4.2 \u00b1 0.2) \u00d7 10<jats:sup>5<\/jats:sup> M<jats:sup>-1<\/jats:sup>], support the fact that the significant\namount of the drug could be transported and distributed through the cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>All \u03b2-diketonates exhibited better scavenging activities than their corresponding copper\ncomplexes. Among all the tested compounds, 2E gave the highest reducing power, even higher\nthan standard ascorbic acid, while reducing power for compounds 2A and 2B was also good but\nlower than standard. DNA and BSA binding study for 2E showed that this compound has the potential\nto be used as medicament.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406415666191024102520","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T12:41:55Z","timestamp":1573130515000},"page":"519-532","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Synthesis, Characterization, Antioxidant Activity of \u03b2-diketonates, and Effects of Coordination to Copper(II) Ion on their Activity: DNA, BSA Interactions and Molecular Docking Study"],"prefix":"10.2174","volume":"17","author":[{"given":"Nenad","family":"Joksimovi\u0107","sequence":"first","affiliation":[{"name":"University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Petronijevi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Jankovi\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac, Department of Sciences, Institute of Information Technologies Kragujevac, Jovana Cvijica bb, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Kosani\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac, Faculty of Science, Department of Biology and Ecology, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161an","family":"Milivojevi\u0107","sequence":"additional","affiliation":[{"name":"Vin\u010da Institute of Nuclear Science University of Belgrade, P.O. Box 522, 11001, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Vrane\u0161","sequence":"additional","affiliation":[{"name":"University of Novi Sad, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovi\u0107a 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Tot","sequence":"additional","affiliation":[{"name":"University of Novi Sad, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovi\u0107a 3, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorica","family":"Bugar\u010di\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovi\u0107a 12, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/176108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/176108\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/176108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:55:30Z","timestamp":1622037330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/176108\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,24]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573406415666191024102520","relation":{},"ISSN":["1573-4064"],"issn-type":[{"value":"1573-4064","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,24]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}