{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:56:03Z","timestamp":1762520163797},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2020,11,23]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>Medicinal Chemistry has played a critical role in evolving new products, resources and\nprocesses which inexorably correspond to our high standards of living. Unfortunately, this has also\ncaused deterioration of human health and threats to the global environment, even deaths when highly\nexposed to certain chemicals, whether due to improper use, mishandling or disposal. There are\nchemicals, which apart from being carcinogens, endocrine disruptors or neurotoxins, are also responsible\nfor climate change and ozone depletion. Certain chemicals are known to cause neurotoxicity\nand are having tendencies to damage the central and peripheral nervous system or brain by damaging\nneurons or cells which are responsible for transmitting and processing of signals. This has\nraised serious concerns for the use and handling of such chemicals and has given growth to a relatively\nnew emerging field known as Green Chemistry that strives to achieve sustainability at the\nmolecular level and has an ability to harness chemicals to meet environmental and economic goals.\nIt has been reported in the literature that apart from family history in the aetiology of Amyotrophic\nlateral Sclerosis (ALS), also termed as \u201cLou Gehrig\u2019s disease\u201d, a neurological disorder, environmental\nfactors, heavy metals, particularly selenium, lead, mercury, cadmium, formaldehyde, pesticides\nand certain herbicides are known to cause ALS. ALS, a progressive neurodegenerative disease\naffects the motor cortex, brain stem and spinal cord, causing muscular weakness, spasticity, and\nhyperreflexia. In this article we are aiming to discuss and summarize the various corroborations and\nfindings supporting the undesirable role of chemical substance\/herbicides\/pesticides in ALS aetiology\nand its mitigation by adopting green chemistry.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406416666200413111330","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T18:53:31Z","timestamp":1586804011000},"page":"1058-1068","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Denouement of Chemicals on Amyotrophic Lateral Sclerosis: Is Green Chemistry the Answer"],"prefix":"10.2174","volume":"16","author":[{"given":"Faizana","family":"Fayaz","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Sector-III, MB Road, Pushp Vihar, New Delhi 110017, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faheem H.","family":"Pottoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadat","family":"Shafi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Medicine, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushtaq A.","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research-Kolkata, 163, Maniktala Main Road, Kolkata 700054, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Wakode","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Sector-III, MB Road, Pushp Vihar, New Delhi 110017, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Sector-III, MB Road, Pushp Vihar, New Delhi 110017, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/180844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T06:15:58Z","timestamp":1606198558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/180844\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,23]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,11,23]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573406416666200413111330","relation":{},"ISSN":["1573-4064"],"issn-type":[{"value":"1573-4064","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,23]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}