{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:31:20Z","timestamp":1771068680139,"version":"3.50.1"},"reference-count":32,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>\u03b1-Glucosidase is a hydrolyzing enzyme that plays a crucial role in the degradation\nof carbohydrates and starch to glucose. Hence, \u03b1-glucosidase is an important target in carbohydrate\nmediated diseases such as diabetes mellitus.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized\nand evaluated against \u03b1-glucosidase in vitro and in silico.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>These compounds were obtained from the reaction between 4-(bromomethyl)-7-\nmethoxy-2H-chromen-2-one 1, carbon disulfide 2, and primary or secondary amines 3a-n in the\npresence of potassium hydroxide and ethanol at room temperature. In vitro \u03b1-glucosidase inhibition\nand kinetic study of these compounds were performed. Furthermore, a docking study of the most\npotent compounds was also performed by Auto Dock Tools (version 1.5.6).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Obtained results showed that all the synthesized compounds exhibited prominent inhibitory\nactivities (IC50 = 85.0 \u00b1 4.0-566.6 \u00b1 8.6 \u03bcM) in comparison to acarbose as a standard inhibitor\n(IC50 = 750.0 \u00b1 9.0 \u03bcM). Among them, the secondary amine derivative 4d with pendant indole\ngroup was the most potent inhibitor. Enzyme kinetic study of the compound 4d revealed that this\ncompound competes with a substrate to connect to the active site of \u03b1-glucosidase and therefore is\na competitive inhibitor. Moreover, a molecular docking study predicted that this compound interacted\nwith the \u03b1-glucosidase active site pocket.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our results suggest that the coumarin-dithiocarbamate scaffold can be a promising lead\nstructure for designing potent \u03b1-glucosidase inhibitors for the treatment of type 2 diabetes.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406416666200826101205","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T20:31:44Z","timestamp":1598473904000},"page":"264-272","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Novel Coumarin Containing Dithiocarbamate Derivatives as Potent \u03b1-Glucosidase Inhibitors for Management of Type 2 Diabetes"],"prefix":"10.2174","volume":"17","author":[{"given":"Marjan","family":"Mollazadeh","sequence":"first","affiliation":[{"name":"School of Chemistry, College of Science, University of Tehran, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mohammadi-Khanaposhtani","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Valizadeh","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsaneh","family":"Zonouzi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A.","family":"Faramarzi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Kiani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmood","family":"Biglar","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bagher","family":"Larijani","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haleh","family":"Hamedifar","sequence":"additional","affiliation":[{"name":"CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Mahdavi","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mir Hamed","family":"Hajimiri","sequence":"additional","affiliation":[{"name":"Nano Alvand Company, Avicenna Tech Park, Tehran University of Medical Sciences, Tehran,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","volume":"37","author":"Reaven G.M.","year":"1988","unstructured":"Reaven G.M.; Banting lecture 1988. 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