{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:41:12Z","timestamp":1774129272773,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Alzheimer\u2019s Disease (AD) is one of the most common neurodegenerative\ndisorders, characterized by memory deficits and cognitive impairment. Acetylcholinesterase inhibitors,\nNMDA receptor antagonists and nootropic agents are used clinically, but they have only symptomatic\nefficacy, attributed to the multifactorial character of AD. The multi-target directed compound\napproach is gaining attention and has been under investigation lately.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This review selects several research articles, which describe the design, synthesis and biological\nevaluation of multi-targeting molecules combining antioxidant or\/and anti-inflammatory\nproperties. Compounds with these properties are expected to be beneficial in the treatment of AD.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This review summarizes the pathobiochemistry of AD as well as the role of oxidative stress\nand inflammation in the progression of neurodegeneration. It presents novel compounds with antioxidant\nor\/and anti-inflammatory activity that have been tested for their efficacy in neurodegenerative\ndisorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Various researchers have taken advantage of the multi-targeting drug approach in order to\ndesign molecules which may be developed as useful agents for the treatment of neurodegeneration.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The multi-targeting compound approach is a developing therapeutic strategy for multifactorial\ndiseases, such as AD, and can offer effective agents for their radical treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406416666201013161303","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T06:21:03Z","timestamp":1602656463000},"page":"1086-1103","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Multi-Target Directed Compounds with Antioxidant and\/or Anti- Inflammatory Properties as Potent Agents for Alzheimer\u2019s Disease"],"prefix":"10.2174","volume":"17","author":[{"given":"Georgios","family":"Papagiouvannis","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia, 1036, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Theodosis-Nobelos","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Health Sciences, Frederick University, Nicosia, 1036, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panos N.","family":"Kourounakis","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni A.","family":"Rekka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186843\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T16:51:36Z","timestamp":1637340696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186843\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573406416666201013161303","relation":{},"ISSN":["1573-4064"],"issn-type":[{"value":"1573-4064","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}