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Thus, the search for new molecules that possess antimalarial\nactivity is constant and extremely important. However, the potential that an antimalarial\ndrug possesses cannot be ignored, and molecular hybridization is a good strategy to design new\nchemical entities.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This review article aims to emphasize recent advances in the biological activities of new\n1,2,3-triazole- and quinoline-based hybrids and their place in the development of new biologically\nactive substances. More specifically, it intends to present the synthetic methods that have been utilized\nfor the syntheses of hybrid 1,2,3-triazoles with quinoline nuclei.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method:<\/jats:title>\n<jats:p>We have comprehensively and critically discussed all the information available in the literature\nregarding 1,2,3-triazole- and quinoline-based hybrids with potent antiplasmodial activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The quinoline nucleus has already been proven to lead to new chemical entities in the pharmaceutical\nmarket, such as drugs for the treatment of malaria and other diseases. The same can be\nsaid about the 1,2,3-triazole heterocycle, which has been shown to be a beneficial scaffold for the\nconstruction of new drugs with several activities. However, only a few triazoles have entered the\npharmaceutical market as drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Many studies have been conducted to develop new substances that may circumvent the\nresistance developed by the parasite that causes malaria, thereby improving the therapy currently\nused.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573406418666211110143041","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T04:29:20Z","timestamp":1636604960000},"page":"521-535","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["1,2,3-Triazole- and Quinoline-based Hybrids with Potent Antiplasmodial Activity"],"prefix":"10.2174","volume":"18","author":[{"given":"Vitor F.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Departamento de Tecnologia Farmac\u00eautica, Faculdade de Farm\u00e1cia,\nUniversidade Federal Fluminense, 24241-000, Niter\u00f3i, RJ, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela A.","family":"Graciano","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Campus do\nValonguinho, 24020-141 Niter\u00f3i, RJ, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alcione S.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Campus do\nValonguinho, 24020-141 Niter\u00f3i, RJ, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-3778","authenticated-orcid":true,"given":"Fernando","family":"de Carvalho da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal Fluminense, Campus do\nValonguinho, 24020-141 Niter\u00f3i, RJ, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1136\/bmj.296.6635.1486","volume":"296","author":"Bruce-Chwatt L.","year":"1988","unstructured":"Bruce-Chwatt L.; Three hundred and fifty years of the Peruvian fever bark. 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