{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:43:28Z","timestamp":1756572208722,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"6","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAD"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Tuberculosis, is a chronic infectious disease, affects one third of the global population. Emergence\nof Multi-resistant (MDR) strains and high susceptibility of human immunodeficiency virus (HIV) infected persons to the\ndisease forced to develop novel anti-tuberculosis agents and preferably have a novel mechanism of action as to avoid crossresistant with other agents. Literature survey evidences that, Pyridine, Thiadiazole , Benzimidazole; and Acetyl thiophene\nderivatives exhibit various pharmacological activities, including anti-mycobacterial activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Thus, a series of Pyridine, Thiadiazole, Benzimidazole; and Acetyl thiophene based molecules were designed and\ndocked against crucial mtb enzyme target InhA (Enoyl Acyl Carrier Protein Reductase) Enzyme. The docked molecules\nwere screened against good docking-score and multiple interactions and opted for synthesis. Synthesized molecules were re\ncrystallized to obtain the purity. All the purified compounds were characterized by various spectral analyses and evaluated\nfor anti- mycobacterial activity against tuberculosis H37RV strain by Microplate Alamar Blue Assay (MABA) method.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The experimental results shown that schiff base of Pyridine (Compounds \u2018d\u2019 ) and Benzimidazole derivatives\n(Compounds \u2018i\u2019 ) possesses good anti-tubercular activity with a MIC below 1.6 \u03bcg \/mL. Further compound \u2018e\u2019 of\nbenzimdazole derivative showed good anti tubercular activity with an MIC below 6.25 \u03bcg \/mL. Whereas 2 - acetyl thiopene\ncompounds exhibited moderate anti tubercular activity at below 50\u03bcg\/mL.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The comparative in vitro and molecular docking study analysis reveals that, compared to chalcones of Acetyl\nthiophne derivatives, Pyridine, thiadazole and Benzimidazole based schiff bases exhibited best anti tubercular activity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573409916666200724152827","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T03:33:54Z","timestamp":1595820834000},"page":"773-784","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design, Synthesis and In Vitro Biological Evaluation of Pyridine, Thiadazole,\nBenzimidazole and Acetyl Thiophene Analogues as Anti Tubercular\nAgents Targeting Enzyme Inh A"],"prefix":"10.2174","volume":"17","author":[{"given":"Ayyadurai J","family":"Suresh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Affiliated to \u201cThe Tamil Nadu Dr. M.G.R Medical University\u201d Chennai - 600 003, Tamil, Nadu,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivashankar","family":"Nandini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Affiliated to \u201cThe Tamil Nadu Dr. M.G.R Medical University\u201d Chennai - 600 003, Tamil, Nadu,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnanmurthy","family":"Sangeetha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Affiliated to \u201cThe Tamil Nadu Dr. M.G.R Medical University\u201d Chennai - 600 003, Tamil, Nadu,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-5390","authenticated-orcid":true,"given":"Loganathan S","family":"Dhivya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Affiliated to \u201cThe Tamil Nadu Dr. M.G.R Medical University\u201d Chennai - 600 003, Tamil, Nadu,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-2751","authenticated-orcid":true,"given":"Parakkot R","family":"Surya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Affiliated to \u201cThe Tamil Nadu Dr. M.G.R Medical University\u201d Chennai - 600 003, Tamil, Nadu,India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Computer-Aided Drug Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/184100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.eurekaselect.com\/184100\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eurekaselect.com\/article\/download\/184100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T07:42:57Z","timestamp":1642750977000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/184100\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573409916666200724152827","relation":{},"ISSN":["1573-4099"],"issn-type":[{"type":"print","value":"1573-4099"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}