{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:32:46Z","timestamp":1784975566906,"version":"3.55.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAD"],"published-print":{"date-parts":[[2021,12]]},"abstract":"\nBackground:<\/jats:title>\n AT1R (Angiotensin II type 1 receptor) is the main component of RAS (renin-angiotensin system)\nsystem which activates when ANG II (angiotensin II) binds to it. AT1R helps in maintaining osmotic homeostasis and\nblood pressure regulation. A huge number of polymorphism is associated with AT1R and few of them were studied and\nfound to be associated with the diseases and drug efficacy. Although it is very important receptor but most of the\npolymorphisms (SNPs) were not studied for their implications in diseases. Huge number of polymorphisms is reported in\nthe databases for AT1R which provide an avenue to explore these polymorphisms for their implications in protein\nstructure, function and drug efficacy.<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:title>\n In the current study all the SNPs (10234) reported in NCBI were analyzed and SNPs which were important in\nprotein structure and drug interactions were identified. Structures of these polymorphic forms were modeled and in silico\ndrug interaction studies were carried out.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\n Result of the interaction studies with polymorphism was in correlation with the reported case. Two SNP mutated\nstructures of AT1R i.e. rs780860717 (G288T), rs868647200 (A182C) shows considerably less binding affinities in case of\nall angiotensin receptor blockers (ARBs). As a result these polymorphisms may show less efficacy toward these ARBs.\nThe other mutated structures rs12721226 (A163G), rs749234826 (A292G), rs775810028 (A87G) shows increased binding\naffinities in case of Eprosartan and most of the mutated structures shows increased binding affinity toward Telmisartan\nthan the wild type AT1R. Similarly, these polymorphisms may show increased efficacy in case of these two ARBs.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nThe outcome of the study will help in designing better drugs in near future with broader spectrum.\nFurthermore in vitro and in vivo studies can be designed according to current results.\n<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573409916666201023113709","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T04:06:02Z","timestamp":1603685162000},"page":"927-935","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["In silico Approach for Exploring the Role of AT1R Polymorphism on its\nFunction, Structure and Drug Interactions"],"prefix":"10.2174","volume":"17","author":[{"given":"Bhanu","family":"Sharma","sequence":"first","affiliation":[{"name":"Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences,\nSolan-173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"School of Electrical and Computer Science Engineering, Shoolini University\nof Biotechnology and Management Sciences, Solan-173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Azhar","family":"Khan","sequence":"additional","affiliation":[{"name":"Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences,\nSolan-173229, Himachal Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Computer-Aided Drug Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/187144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.eurekaselect.com\/187144\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/eurekaselect.com\/article\/download\/187144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T14:39:41Z","timestamp":1641998381000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/187144\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1573409916666201023113709","relation":{},"ISSN":["1573-4099"],"issn-type":[{"value":"1573-4099","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}