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Kaposi's Sarcoma (KS) tumor can appear as painless purple\nspots on the legs, foot, or face. This cancer develops in the lining of lymph arteries and blood vessels.\nAlong with the enlargement of lymph nodes, the vaginal region and the mouth portion are the\nadditional target areas of KS. DNA-binding proteins known as Sox proteins are found in all\nmammals and belong to the HMG box superfamily. They controlled a wide range of developmental\nprocedures, such as the formation of the germ layer, the growth of organs, and the selection of\nthe cell type. Human developmental abnormalities and congenital illnesses are frequently caused\nby the deletion or mutation of the Sox protein.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aim:<\/jats:title>\n<jats:p>The purpose of this study is to determine the promising Kaposi's sarcoma inhibitors through\ncomputational studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>In this present study computational approaches were used to evaluate the anti- carcinogenic\nefficacy against Kaposi's sarcoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Ligand-based pharmacophore screening was performed utilising four different chemical\nlibraries (Asinex, Chembridge, Specs, and NCI Natural products (NSC)) depending on the top\nhypothesis. The top hits were examined using molecular docking, absorption, distribution, metabolism\nand excretion. Highest occupied molecular orbital and lowest unoccupied molecular orbital\nwere analysed to determine the lead compounds' biological and pharmacological efficacy. The\nresults of the study indicated that the leading candidates were possible SOX protein inhibitors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The results revealed that the top hits responded to all of the pharmacological druglikening\ncriteria and had the best interaction residues, fitness scores, and docking scores. The resulting\nleads might be potential Kaposi's Sarcoma alternative treatments.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1573409919666230428100646","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:27:29Z","timestamp":1683095249000},"page":"248-263","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Computational Investigation on Chitosan Derivatives using Pharmacophore-\nbased Screening, Molecular Docking, and Molecular Dynamics\nSimulations against Kaposi Sarcoma"],"prefix":"10.2174","volume":"20","author":[{"given":"Kiruba","family":"Sakthivel","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Ganapathy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirubhanand","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Department of Anatomy, All India Institute of Medical Sciences, Nagpur, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gowtham Kumar","family":"Subbaraj","sequence":"additional","affiliation":[{"name":"Faculty of Allied Health Sciences, Chettinad Hospital &amp; Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Langeswaran","family":"Kulanthaivel","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1186\/s13104-015-1348-9","volume":"8","author":"Chalya P.L.","year":"2015","unstructured":"Chalya P.L.; Mbunda F.; Rambau P.F.; Jaka H.; Masalu N.; Mirambo M.; Mushi M.F.; Kalluvya S.E.; Kaposi\u2019s sarcoma: A 10-year experience with 248 patients at a single tertiary care hospital in Tanzania. 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