{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:00:55Z","timestamp":1649008855851},"reference-count":37,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCP"],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Benzodiazepine is one of the most important causes of substance abuse\nand intoxication throughout the world and Iran.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of our study is to determine the role of stimulants in reversing CNS level in\nacute Benzodiazepine poisoning patients who were hospitalized at referral poison center.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This was a randomized double-blind placebo-controlled trial study on 32 cases with pure\nacute Benzodiazepine poisoning from March 2016 to February 2017. Diagnosis of pure acute poisoning\nwas based on history, and laboratory confirmation. We gathered the demographics, clinical\ndata, laboratory data, hospitalization and outcome. Participants were randomized into two groups:\nMethylphenidate Group (MPH) and Placebo Group (PBO).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The randomized sample consisted of 32 participants who were predominately female\n(83%). The majority of the PBO group and the MPH group reported improvement in their consciousness\nwith a significant difference between the two groups (p = .005). Paired sample t-test\nanalyses on Reed Scale data revealed an increase in the probability of improvement during the trial\nfor the MPH group compared to the PBO group. Furthermore, the HCo3 (bicarbonate) level has a\nsignificant p-value with respect to age groups (p = .02). None of our cases required either the ICU\nfacility or intubation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our study provided the MPH superiority over PBO in reversing CNS symptoms in loss\nof consciousness in acute BZD poisoned patients. Thus, this trial provides concrete evidence that\nimprovement in consciousness levels (Reed Scale rated) among those patients receiving MPH was\nassociated with a methylphenidate use.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1574884714666190112153157","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T11:22:41Z","timestamp":1547637761000},"page":"81-88","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Methylphenidate on Reed Scaling in Benzodiazepine Poisoning: A Prospective Trial"],"prefix":"10.2174","volume":"15","author":[{"given":"Masoud","family":"Latifi-Pour","sequence":"first","affiliation":[{"name":"Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Hassanian-Moghaddam","sequence":"additional","affiliation":[{"name":"Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helya-Sadat","family":"Mortazavi","sequence":"additional","affiliation":[{"name":"Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Shadnia","sequence":"additional","affiliation":[{"name":"Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim","family":"Zamani","sequence":"additional","affiliation":[{"name":"Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Toxicological Research Center and Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Kamali Avenue, South Karegar Street, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s13181-014-0391-6","volume":"10","author":"Moore P.W.","year":"2014","unstructured":"Moore P.W.; Donovan J.W.; Burkhart K.K.; Waskin J.A.; Hieger M.A.; Adkins A.R.; Wert Y.; Haggerty D.A.; Rasimas J.J.; Safety and efficacy of flumazenil for reversal of iatrogenic benzodiazepine-associated delirium toxicity during treatment of alcohol withdrawal, a retrospective review at one center. 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