{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:00:09Z","timestamp":1793710809302,"version":"4.6.1"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"1","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCP"],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The present work aimed to evaluate the chemical composition of Curcuma\nzadoaria essential oil and to investigate its efficacy and safety against hydatid cyst protoscoleces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Collected protoscoleces from liver fertile hydatid cysts of infected sheep were exposed to\ndifferent concentrations of the essential oil (75, 150, 300 \u03bcl\/mL) for 5-30 min in vitro and ex vivo.\nThen, by using the eosin exclusion assay, the viability of protoscoleces was studied. In the next\nstep, 24 male NMRI mice were examined to assess the toxicity of C. zadoaria essential oil by measuring\nthe biochemical and hematological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Based on the obtained results, the LD50 value of intraperitoneal injection of the C. zadoaria\nessential oil was 1.76 mL\/kg of body weight and the maximum non-fatal dose was 0.96 mL\/kg of\nbody weight. C. zadoaria essential oil had a strong proto scolicidal activity in vitro so that at the\n300 and 150 \u03bcl\/ml entirely eliminates the parasite after 5 and 10 minutes; whereas, weak proto\nscolicidal activity was observed at lower doses. Ex vivo assay, no similar effect with in vitro was\nobserved, therefore, more time is required to show a potent proto scolicidal activity. C. zadoaria\nessential oil at the concentrations of 300 and 150 \u03bcl\/mL after an exposure time of 7 and 12 min,\nkilled 100% of protoscoleces within the hydatid cyst, respectively. After intraperitoneal injection of\nthe C. zadoaria essential oil for 2 weeks, no significant difference (p &gt; 0.05) was observed in the\nclinical chemistry and hematologic parameters at the doses of 0.15, 0.3, 0.6 mL\/kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The obtained results in vitro and ex vivo exhibited that C. zadoaria essential oil had a\nfavorable proto scolicidal activity on hydatid cyst protoscoleces. However, more supplementary\nworks are required to verify these findings by assessing clinical subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574884714666190918155147","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T08:47:16Z","timestamp":1568796436000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy and Safety Curcuma zadoaria L. to Inactivate the Hydatid Cyst Protoscoleces"],"prefix":"10.2174","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-393X","authenticated-orcid":true,"given":"Hossein","family":"Mahmoudvand","sequence":"first","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-638X","authenticated-orcid":true,"given":"Mahbobeh","family":"Pakravanan","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, Deputy of Research, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-0703","authenticated-orcid":true,"given":"Farnaz","family":"Kheirandish","sequence":"additional","affiliation":[{"name":"Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-7337","authenticated-orcid":true,"given":"Sareh","family":"Jahanbakhsh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-324X","authenticated-orcid":true,"given":"Maryam","family":"Sepahvand","sequence":"additional","affiliation":[{"name":"Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-910X","authenticated-orcid":true,"given":"Massumeh","family":"Niazi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-0250","authenticated-orcid":true,"given":"Abdolreza","family":"Rouientan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2148-6690","authenticated-orcid":true,"given":"Mohammad R.","family":"Aflatoonian","sequence":"additional","affiliation":[{"name":"Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"231","volume":"74","year":"1996","unstructured":"World Health Organization (WHO) informal working group on echinococcosis. 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