{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:45:30Z","timestamp":1787024730869,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"2","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["58323"],"award-info":[{"award-number":["58323"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CCP"],"published-print":{"date-parts":[[2020,10,14]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neonatal Respiratory Distress Syndrome (NRDS) is one of the most frequent\ncauses of neonatal mortality especially in premature infants. Although it has been well established\nthat maternal antenatal corticosteroid therapy has a positive effect on NRDS reduction, yet\nthe effectiveness of this treatment in multifetal pregnancies is dubious.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to investigate the effect of betamethasone therapy on the incidence of NRDS\nin multifetal pregnancies through a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>140 women with a multifetal pregnancy at less than 28 weeks\u2019 gestational age were randomly\nallocated into intervention and control groups. Women at the intervention group received\nintramuscularly betamethasone (12 mg\/kg\/BW twice). Neonatal outcomes were evaluated between\ntwo groups of intervention and control, and two subgroups of preterm and term births. This study is\nregistered with the Iranian Clinical Trials Registry, number IRCT20180227038879N1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>The incidence of NRDS was significantly lower in infants of betamethasone group than the\nones in the control group (4.9% vs 18.1%, P=0.034) while it did not show a significant reduction in\npreterm infants compared to mature ones. Also, the intervention group presented a significant lower\nneonatal ventilation than the control group (47.2% vs 63.2%, P=0.041). Other neonatal outcomes,\nincluding age at birth, birth weight, Apgar score, NICU admission, and the number of mortalities\nwere not significantly different between study groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Betamethasone therapy during 28-32 weeks of gestation in multifetal pregnancies was\nassociated with better neonatal outcomes through significant reductions in NRDS incidence and\nrequiring ventilator treatment. However, betamethasone administration did not reduce the chance of\nNRDS in premature infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1574884714666191007154936","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T07:58:17Z","timestamp":1570607897000},"page":"164-169","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal Administration of Betamethasone and Neonatal Respiratory Distress Syndrome in Multifetal Pregnancies: A Randomized Controlled Trial"],"prefix":"10.2174","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3518-1924","authenticated-orcid":true,"given":"Fatemeh","family":"Abbasalizadeh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Women\u2019s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-5713","authenticated-orcid":true,"given":"Khadijeh","family":"Pouya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raana","family":"Zakeri","sequence":"additional","affiliation":[{"name":"Department of Health Services Management, School of Management and Medical Informatics, Iranian International Safe Community Support Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4056-1238","authenticated-orcid":true,"given":"Rana","family":"Asgari-Arbat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Women\u2019s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-6618","authenticated-orcid":true,"given":"Shamsi","family":"Abbasalizadeh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Women\u2019s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Parnianfard","sequence":"additional","affiliation":[{"name":"Research Center for Evidence-Based Medicine, Drug Applied Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/175409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T14:36:39Z","timestamp":1607783799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/175409\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,10,14]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1574884714666191007154936","relation":{},"ISSN":["1574-8847"],"issn-type":[{"value":"1574-8847","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,14]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}